An arrangement structure of a vehicle door open-close device to automatically open and close a vehicle door by a driving force. The arrangement structure comprises of a roof member, a side member, and a gazette member. The roof member is provided on a door-opening area for constituting a ceiling member of a vehicle body. The side member is provided on the door-opening area for constituting a side portion of a vehicle body. The gazette member is provided on the door-opening area for being attached to the roof member and the side member so as to extend over the roof member and the side member. Furthermore, the vehicle door open-close device is ranged in a space surrounded by the roof member, the side member, and the gazette member.