发明授权
US07091229B2 Tricyclic lactam and sultam derivatives and their use as histone deacetylase inhibitors
失效
三环内酰胺和苏丹衍生物及其作为组蛋白脱乙酰酶抑制剂的用途
- 专利标题: Tricyclic lactam and sultam derivatives and their use as histone deacetylase inhibitors
- 专利标题(中): 三环内酰胺和苏丹衍生物及其作为组蛋白脱乙酰酶抑制剂的用途
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申请号: US10470121申请日: 2002-01-24
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公开(公告)号: US07091229B2公开(公告)日: 2006-08-15
- 发明人: Guy Georges , Adelbert Grossmann , Olaf Mundigl , Wolfgang von der Saal , Tim Sattelkau
- 申请人: Guy Georges , Adelbert Grossmann , Olaf Mundigl , Wolfgang von der Saal , Tim Sattelkau
- 申请人地址: US NJ Nutley
- 专利权人: Hoffman-La Roche Inc.
- 当前专利权人: Hoffman-La Roche Inc.
- 当前专利权人地址: US NJ Nutley
- 代理商 George W. Johnston; Patricia S. Rocha-Tramaloni; Brian C. Remy
- 优先权: EP01101873 20010127
- 国际申请: PCT/EP02/00705 WO 20020124
- 国际公布: WO02/062773 WO 20020815
- 主分类号: A61K31/425
- IPC分类号: A61K31/425 ; A61K31/403 ; C07D275/06 ; C07D209/56
摘要:
A compound of formula (I) wherein A and B are optionally substituted cyclohexenyl or phenyl groups, X is carbonyl or sulfonyl, and Y is 5–7 atoms-linker, is useful as histone deacetylase inhibitors, particularly for inhibiting cell proliferation.
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