-
公开(公告)号：US4866205A
公开(公告)日：1989-09-12
申请号：US218427
申请日：1988-07-11
IPC分类号： C07C405/00 , C07D307/935
CPC分类号： C07D307/935 , C07C405/00 , C07C405/0041
摘要： New optically active intermediates and processes thereto are provided for use in synthesizing therapeutically active prostaglandins of the formula: ##STR1## wherein R.sup.1 is hydrogen or lower alkyl; from a compound of the formula: ##STR2## wherein R.sup.1 is as above and R.sup.2 is hydrogen or a carboxy blocking group convertible to an acid by hydrolysis.
摘要翻译： 提供新的光学活性中间体及其方法用于合成下式的治疗活性的前列腺素：其中R 1是氢或低级烷基; 由下式的化合物：其中R1如上所述，R2是氢或通过水解可转化成酸的羧基封端基团。
-
公开(公告)号：US12031891B2
公开(公告)日：2024-07-09
申请号：US16955337
申请日：2018-12-20
摘要： The method includes fixing the tissue sample with a first fixation solution immersing the tissue sample in a delipidation solution including a chaotropic agent configured to induce a swelling of the sample; staining the tissue sample; dehydrating the tissue sample in an organic dehydration solution, the dehydration solution configured to induce a shrinking of the sample; and immersing the fixed tissue sample in an organic clearing solution.
-
公开(公告)号：US20230279155A1
公开(公告)日：2023-09-07
申请号：US18317385
申请日：2023-05-15
CPC分类号： C07K16/468 , C07K16/1232 , C07K16/22 , C07K16/243 , C07K16/248 , C07K16/40 , C12N15/1058 , C07K2317/24 , C07K2317/565 , C07K2317/92
摘要： The present invention relates to antibody-based dual targeting molecules, and to methods for generating such dual targeting molecules, including a library-based approach.
-
公开(公告)号：US20230206438A1
公开(公告)日：2023-06-29
申请号：US18172682
申请日：2023-02-22
发明人： Zhuang Song , Nils Gustav Thomas Bengtsson , Richard Alan Duray Carano , David B. Clayton , Alexander James Stephen Champion De Crespigny , Laura Gaetano , Anitha Priya Krishnan
CPC分类号： G06T7/0012 , G06T7/11 , G06T9/002 , G16H30/40 , G16H50/20 , G06T2200/04 , G06T2207/10088 , G06T2207/20021 , G06T2207/20081 , G06T2207/20084 , G06T2207/30016 , G06T2207/30096
摘要： Embodiments disclosed herein generally relate to multi-arm machine learning models for lesion detection. Particularly, aspects of the present disclosure are directed to accessing a three-dimensional magnetic resonance imaging (MRI) images. Each of the three-dimensional MRI images depict a same volume of a brain of a subject. The volume of the brain includes at least part of one or more lesions. Each three-dimensional MRI image of the three-dimensional MRI images is processed using one or more corresponding encoder arms of a machine-learning model to generate an encoding of the three-dimensional MRI image. The encodings of the three-dimensional MRI images are concatenated to generate a concatenated representation. The concatenated representation is processed using a decoder arm of the machine-learning model to generate a prediction that identifies one or more portions of the volume of the brain predicted to depict at least part of a lesion.
-
公开(公告)号：US20220319003A1
公开(公告)日：2022-10-06
申请号：US17725765
申请日：2022-04-21
发明人： Thomas Felix ALBRECHT , Filippo ARCADU , Fethallah BENMANSOUR , Yun LI , Andreas MAUNZ , Jayashree SAHNI , Andreas THALHAMMER , Yan-Ping ZHANG SCHAERER
摘要： Methods and systems disclosed herein relate generally to systems and methods for predicting a future visual acuity of a subject by using machine-learning models. An image of at least part of a retina of a subject can be processed by one or more first machine-learning models to detect a set of retina-related segments. Segment-specific metrics that characterize a retina-related segment of the set of retina-related segments can be generated. The segment-specific metrics can be processed by using a second machine-learning model to generate a result corresponding to a prediction corresponding to a future visual acuity of the subject.
-
![Solid forms of 3-((1R,3R)-1-(2,6-difluoro-4-((1-(3- fluoropropyl)azetidin-3-yl)amino)phenyl)-3-methyl-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)-2,2-difluoropropan-1-ol and processes for preparing fused tricyclic compounds comprising a substituted phenyl or pyridinyl moiety, including methods of their use](/abs-image/US/2021/03/23/US10954234B2/abs.jpg.150x150.jpg)
公开(公告)号：US10954234B2
公开(公告)日：2021-03-23
申请号：US16443515
申请日：2019-06-17
发明人： Cheol Keun Chung , Jie Xu , Hans Iding , Kyle Clagg , Michael Dalziel , Alec Fettes , Francis Gosselin , Ngiap-Kie Lim , Andrew McClory , Haiming Zhang , Paroma Chakravarty , Karthik Nagapudi , Sarah Robinson
IPC分类号： C07D471/04 , C07D403/14 , A61P35/00 , A61P35/04
摘要： Provided herein are solid forms, salts, and formulations of 3-((1R,3R)-1-(2,6-difluoro-4-((1-(3-fluoropropyl)azetidin-3-yl)amino)phenyl)-3-methyl-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)-2,2-difluoropropan-1-ol, processes and synthesis thereof, and methods of their use in the treatment of cancer.
-
公开(公告)号：US10825195B2
公开(公告)日：2020-11-03
申请号：US16091245
申请日：2017-03-02
发明人： Franziska Mech , Angelika Fuchs , Jan Kuentzer , Otto Huber , Alex Kohn , Eckhart Guthoehrlein
IPC分类号： G06T7/73 , G06T7/00 , G06T7/50 , G06T7/30 , G16H30/20 , G06F16/51 , G06K9/00 , G06K9/62 , G06T7/60
摘要： An image analysis method for analyzing an IHC tissue sample includes storing, for each of one or more sets of digital images, a set-ID in a spatial database of a spatial DBMS, the images of each set depicting the same or adjacent layers of the IHC tissue sample; storing, for each of the, a plurality of spatial data objects in the database in association with the set-ID; creating, by the spatial DBMS, at least one spatial index covering the objects of the images contained in the one or more sets; applying, by the spatial DBMS, a spatial database operation on the at least one spatial index for determining the relative positions of objects of two or more images of a selected set; and providing the relative positions as input for determining the distance and/or relative position of the biomedical features of the tissue sample.
-
公开(公告)号：US10239876B2
公开(公告)日：2019-03-26
申请号：US15850826
申请日：2017-12-21
发明人： Bernd Buettelmann , Buelent Kocer , Bernd Kuhn , Marco Prunotto , Hans Richter , Martin Ritter , Markus Rudolph , Alexander Lee Satz
IPC分类号： C07D471/10 , C07D519/00 , A61P1/16 , A61P9/00 , A61P37/06 , A61P13/12 , A61P35/00
摘要： The present invention relates to compounds of formula (I): or pharmaceutically acceptable salts thereof, wherein L and R1 to R5 are as described herein, as well as processes for their manufacture, pharmaceutical compositions comprising them, and their use as medicaments.
-
公开(公告)号：US10087234B2
公开(公告)日：2018-10-02
申请号：US14440790
申请日：2013-11-06
发明人： Nicolas Vuilleumier , Sabrina Pagano , Oliver Hartley , Hubert Gaertner , Priscila Camillo Teixeira , Paul Cutler , Philippe Ferber
IPC分类号： A61K38/10 , C07K14/775 , G01N33/543 , A61K38/00
摘要： The invention relates to mimetic peptides of epitope(s) of Apolipoprotein A-I, diagnostic immunoassays comprising such mimetic peptides, as well as methods for diagnosing and methods for preventing and/or treating a cardiovascular disease.
-
公开(公告)号：US10047081B2
公开(公告)日：2018-08-14
申请号：US15558273
申请日：2016-03-16
发明人： Bjoern Bartels , Cosimo Dolente , Wolfgang Guba , Wolfgang Haap , Ulrike Obst Sander , Jens-Uwe Peters , Thomas Woltering
IPC分类号： C07D417/14
摘要： The present invention provides a compound of formula I, having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.
-
-
-
-
-
-
-
-
-
搜索结果
492 条记录 (耗时 0.038 秒)
