发明授权
US07091345B2 Amino-substituted dihydropyrimido[4,5-D]pyrimidinone derivatives
失效
氨基取代的二氢嘧啶并[4,5-D]嘧啶酮衍生物
- 专利标题: Amino-substituted dihydropyrimido[4,5-D]pyrimidinone derivatives
- 专利标题(中): 氨基取代的二氢嘧啶并[4,5-D]嘧啶酮衍生物
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申请号: US10697543申请日: 2003-10-30
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公开(公告)号: US07091345B2公开(公告)日: 2006-08-15
- 发明人: Jianping Cai , Nikolaos Dimoudis , Konrad Honold , Kin-Chun Luk , Stefan Scheiblich , Hilke Sudergat , Georg Tiefenthaler , Oliver Tonn
- 申请人: Jianping Cai , Nikolaos Dimoudis , Konrad Honold , Kin-Chun Luk , Stefan Scheiblich , Hilke Sudergat , Georg Tiefenthaler , Oliver Tonn
- 申请人地址: US NJ Nutley
- 专利权人: Hoffmann-La Roche Inc.
- 当前专利权人: Hoffmann-La Roche Inc.
- 当前专利权人地址: US NJ Nutley
- 代理商 George W. Johnston; Patricia S. Rooha-Tramaloni
- 优先权: EP02024573 20021104
- 主分类号: C07D471/04
- IPC分类号: C07D471/04 ; C07D491/113 ; A61K31/519
摘要:
Compounds of formula I are described. These compounds are protein kinase inhibitors, in particular they inhibit the src family tyrosine kinases. Thus, these compounds are useful for the treatment of diseases mediated by src tyrosine kinases, including cell proliferative disorders such as cancer. Also described are methods of making and using compounds of formula I as well as pharmaceutical compositions containing these compounds.
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