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1.
公开(公告)号:US07091345B2
公开(公告)日:2006-08-15
申请号:US10697543
申请日:2003-10-30
申请人: Jianping Cai , Nikolaos Dimoudis , Konrad Honold , Kin-Chun Luk , Stefan Scheiblich , Hilke Sudergat , Georg Tiefenthaler , Oliver Tonn
发明人: Jianping Cai , Nikolaos Dimoudis , Konrad Honold , Kin-Chun Luk , Stefan Scheiblich , Hilke Sudergat , Georg Tiefenthaler , Oliver Tonn
IPC分类号: C07D471/04 , C07D491/113 , A61K31/519
CPC分类号: C07D487/04 , C07D491/10
摘要: Compounds of formula I are described. These compounds are protein kinase inhibitors, in particular they inhibit the src family tyrosine kinases. Thus, these compounds are useful for the treatment of diseases mediated by src tyrosine kinases, including cell proliferative disorders such as cancer. Also described are methods of making and using compounds of formula I as well as pharmaceutical compositions containing these compounds.
摘要翻译: 描述式I化合物。 这些化合物是蛋白激酶抑制剂,特别是它们抑制src家族酪氨酸激酶。 因此,这些化合物可用于治疗由src酪氨酸激酶介导的疾病,包括细胞增殖性疾病如癌症。 还描述了制备和使用式I化合物的方法以及含有这些化合物的药物组合物。