发明授权
- 专利标题： Functional biopolymer modification reagents and uses thereof
- 专利标题（中）： 功能生物聚合物修饰试剂及其用途
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申请号： US09630060申请日： 2000-08-01
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公开(公告)号： US07102024B1公开(公告)日： 2006-09-05
- 发明人: David A. Schwartz , Richard I. Hogrefe
- 申请人： David A. Schwartz , Richard I. Hogrefe
- 代理机构： David Waller & Assoc.
- 主分类号： C07F9/02
- IPC分类号： C07F9/02 ; C07H21/00
摘要：
Hydrazino, oxyamino and carbonyl-based reagents and methods for incorporation into oligonucleotides during their solid phase synthesis are provided. Modified oligonucleotides are provided that incorporate the reagents provided here in. Immobilized oligonucleotides and oligonucleotide conjugates that contain covalent hydrazone or oxime linkages are provided. Methods for preparation of surface bound oligonucleotides are provided. Methods for the preparation of oligonucleotide conjugates are also provided.
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