发明授权
- 专利标题： Methods and compositions for the manufacture of C-3′ and C-4′ anthracycline antibiotics
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申请号： US10752426申请日： 2004-01-06
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公开(公告)号： US07109177B2公开(公告)日： 2006-09-19
- 发明人: Waldeman Priebe , Izabella Fokt , Teresa Przewloka , Marta Krawczyk , Piotr Skibicki , Grzegorz Grynkiewicz , Roman Perez-Soler
- 申请人： Waldeman Priebe , Izabella Fokt , Teresa Przewloka , Marta Krawczyk , Piotr Skibicki , Grzegorz Grynkiewicz , Roman Perez-Soler
- 申请人地址： US TX Houston
- 专利权人： Houston Pharmaceuticals, Inc.
- 当前专利权人： Houston Pharmaceuticals, Inc.
- 当前专利权人地址： US TX Houston
- 代理机构： Fulbright & Jaworski L.L.P.
- 主分类号： A61K31/70
- IPC分类号： A61K31/70 ; C07H15/24
摘要：
The present invention discloses new and novel substituted anthracyclines with modified alkyl-aromatic ring substitutions on the C-3′ of the sugar moiety or modified or unmodified alkyl-aromatic ring substitutions at the C-4′ of the sugar moiety. It also discloses novel methods for the preparation of sugar substrates and methods for the preparation of anthracycline antibiotics. These anthracycline analogs show high cytotoxicity in vitro against several tumor cell lines.
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