发明授权
- 专利标题： Process for obtaining Cizolirtine and its enantiomers
- 专利标题（中）： 获得Cizolirtine及其对映异构体的方法
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申请号： US11041637申请日： 2005-01-24
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公开(公告)号： US07109349B2公开(公告)日： 2006-09-19
- 发明人: Antoni Torrens Jover , Helmut H. Buschmann , Stefan Dahmen , Matthias Lormann
- 申请人： Antoni Torrens Jover , Helmut H. Buschmann , Stefan Dahmen , Matthias Lormann
- 申请人地址： ES
- 专利权人： Laboratorios Del Dr. Esteve, S/A
- 当前专利权人： Laboratorios Del Dr. Esteve, S/A
- 当前专利权人地址： ES
- 代理机构： Intellectual Property Technology Law
- 代理商 Steven J. Hultquist
- 优先权： EP04380266 20041207
- 主分类号： C07D231/12
- IPC分类号： C07D231/12
摘要：
A process is described for the preparation of a precursor alcohol of Cizolirtine, (±)-2-[phenyl(1-methyl-1H-pyrazol-5-yl)methoxy]-N,N-dimethylethanamine and its enantiomers. The process involves the asymmetric addition of a metalated phenyl reagent to a pyrazolcarbaldehyde in the presence of a chiral ligand to yield chiral alcohols. The chiral alcohols are further O-alkylated to yield Cizolirtine or its enantiomers.
公开/授权文献
- US20060135788A1 PROCESS FOR OBTAINING CIZOLIRTINE AND ITS ENANTIOMERS 公开/授权日：2006-06-22
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