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公开(公告)号：US20090326014A1
公开(公告)日：2009-12-31
申请号：US12308923
申请日：2007-06-29
IPC分类号： A61K31/4418 , A61K31/415
CPC分类号： A61K31/00 , A61K31/415 , A61K31/4418
摘要： The present invention refers to the use of 5-HT7 receptor agonists for the treatment of pain and the symptoms of pain, especially certain subtypes of pain like neuropathic pain and inflammatory pain and symptoms involving allodynia and hyperalgesia, the prevention or the prophylaxis of pain and the symptoms of pain, especially certain subtypes of pain like neuropathic pain and inflammatory pain and symptoms involving allodynia and hyperalgesia.
摘要翻译： 本发明涉及5-HT7受体激动剂用于治疗疼痛和疼痛症状，特别是疼痛的某些亚型，如神经性疼痛和炎性疼痛以及涉及异常性疼痛和痛觉过敏的症状，预防或预防疼痛和 疼痛的症状，特别是某些亚型的疼痛，如神经性疼痛和炎性疼痛以及涉及异常性疼痛和痛觉过敏的症状。
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公开(公告)号：US07109349B2
公开(公告)日：2006-09-19
申请号：US11041637
申请日：2005-01-24
IPC分类号： C07D231/12
CPC分类号： C07D231/12
摘要： A process is described for the preparation of a precursor alcohol of Cizolirtine, (±)-2-[phenyl(1-methyl-1H-pyrazol-5-yl)methoxy]-N,N-dimethylethanamine and its enantiomers. The process involves the asymmetric addition of a metalated phenyl reagent to a pyrazolcarbaldehyde in the presence of a chiral ligand to yield chiral alcohols. The chiral alcohols are further O-alkylated to yield Cizolirtine or its enantiomers.
摘要翻译： 描述了制备Cizolirtine（±）-2- [苯基（1-甲基-1H-吡唑-5-基）甲氧基] -N，N-二甲基乙胺及其对映异构体的前体醇的方法。 该方法包括在手性配体存在下将金属化苯基试剂不对称加成到吡唑甲醛中以产生手性醇。 手性醇进一步O-烷基化以得到西来甜胺或其对映异构体。
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3.发明授权Heterocyclyl substituted tetrahydronaphthalene derivatives as 5-HT7 receptor ligands 失效杂环取代的四氢萘衍生物作为5-HT7受体配体公开(公告)号：US08097641B2
公开(公告)日：2012-01-17
申请号：US12525461
申请日：2008-02-06
IPC分类号： A61K31/415 , C07D231/12
CPC分类号： C07D231/12 , C07D213/64 , C07D261/08
摘要： The present invention relates to heterocyclyl-substituted-tetrahydro-naphthalen compounds of general formula (I), methods for their preparation, and compositions comprising these compounds as well as their use for the treatment or prophylaxis of various disorders in humans or animals.
摘要翻译： 本发明涉及通式（I）的杂环基 - 取代 - 四氢 - 萘化合物，其制备方法和包含这些化合物的组合物及其用于治疗或预防人或动物各种疾病的用途。
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4.发明申请Use of compounds binding to the sigma receptor for the treatment of diabetes-associated pain 审中-公开使用结合σ受体的化合物治疗糖尿病相关的疼痛公开(公告)号：US20090325975A1
公开(公告)日：2009-12-31
申请号：US11991225
申请日：2006-07-27
申请人： Helmut H Buschmann
发明人： Helmut H Buschmann
IPC分类号： A61K31/495 , A61P29/00 , A61K31/132
CPC分类号： A61K31/00
摘要： The present invention refers to the use of compounds active on the sigma receptor for the production of a medicament for the treatment of diabetes-associated pain.
摘要翻译： 本发明涉及在σ受体上活性的化合物在制备用于治疗糖尿病相关性疼痛的药物中的用途。
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公开(公告)号：US20090264457A1
公开(公告)日：2009-10-22
申请号：US12221364
申请日：2008-08-01
IPC分类号： A61K31/437 , A61K31/404 , A61K31/426 , A61K31/416 , A61K31/454 , A61P25/00 , A61P25/28
CPC分类号： A61K31/192 , A61K31/4045 , A61K31/4155 , A61K31/428 , A61K31/429 , A61K31/433 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/63
摘要： The present invention relates to a Combination of at least two 5HT6-Ligands of which one is a partial or agonist while the other is a full antagonist or an inverse agonist, a medicament comprising this comination, the use of the combiantion in the manufacture of a medicament for the treatment of memory disorders ADHD, and methods of treatment using the combination or its members.
摘要翻译： 本发明涉及至少两种5HT6配体的组合，其中一种是部分或激动剂，另一种是完全拮抗剂或反向激动剂，包含该配体的药物，组合物在制备中的用途 用于治疗记忆障碍ADHD的药物，以及使用该组合或其成员的治疗方法。
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6.发明申请USE OF COMPOUNDS BINDING TO THE SIGMA RECEPTOR LIGANDS FOR THE TREATMENT OF NEUROPATHIC PAIN DEVELOPING AS A CONSEQUENCE OF CHEMOTHERAPY 审中-公开使用化合物与SIGMA受体配体结合，用于治疗神经性疼痛发展作为化学疗法的后果公开(公告)号：US20110052723A1
公开(公告)日：2011-03-03
申请号：US12735824
申请日：2009-02-17
申请人： José Manuel Baeyens-Cabrera , Helmut H. Buschmann , José-Miguel Vela-Hernandez , Daniel Zamanillo-Castanedo , Francisco Rafael Nieto-López
发明人： José Manuel Baeyens-Cabrera , Helmut H. Buschmann , José-Miguel Vela-Hernandez , Daniel Zamanillo-Castanedo , Francisco Rafael Nieto-López
IPC分类号： A61K31/495 , A61K33/24 , A61P29/02 , A61P25/02 , A61P25/00
CPC分类号： A61K31/495 , A61K31/137 , A61K31/40 , A61K31/445 , A61K31/4453 , A61K31/451 , A61K31/4515 , A61K31/454 , A61K31/46 , A61K31/5415
摘要： The present invention refers to the use of compounds binding to the sigma receptor for the treatment or prevention of neuropathic pain resulting from chemotherapy.
摘要翻译： 本发明涉及结合σ受体的化合物用于治疗或预防化学疗法引起的神经性疼痛的用途。
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公开(公告)号：US07345057B2
公开(公告)日：2008-03-18
申请号：US11048992
申请日：2005-02-02
申请人： Antoni Torrens Jover , Susana Yenes Minguez , Jose Mas Prio , Luz Romero Alonso , Alberto Dordal Zueras , Helmut H. Buschmann
发明人： Antoni Torrens Jover , Susana Yenes Minguez , Jose Mas Prio , Luz Romero Alonso , Alberto Dordal Zueras , Helmut H. Buschmann
IPC分类号： C07D401/02 , A61K31/4709
CPC分类号： C07B57/00 , C07B2200/07 , C07B2200/11 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
摘要： The invention relates to compounds having pharmacological activity towards the 5-HT7 receptor, and more particularly to some some tetrahydroisoquinoline substituted sulfonamide compounds, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which 5-HT is involved, such as CNS disorders.
摘要翻译： 本发明涉及对5-HT 7受体具有药理活性的化合物，更具体地涉及一些四氢异喹啉取代的磺酰胺化合物，制备这些化合物的方法，包含它们的药物组合物及其用于治疗和/或预防 的5-HT涉及的疾病，如CNS疾病。
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公开(公告)号：US07211585B2
公开(公告)日：2007-05-01
申请号：US10920738
申请日：2004-08-18
申请人： Antoni Torrens Jover , Josep Mas Prio , Susana Yenes Minguez , Monica Garcia Lopez , Alberto Dordal Zueras , Luz Romero Alonso , Helmut H. Buschmann
发明人： Antoni Torrens Jover , Josep Mas Prio , Susana Yenes Minguez , Monica Garcia Lopez , Alberto Dordal Zueras , Luz Romero Alonso , Helmut H. Buschmann
IPC分类号： C07D217/00 , A61K31/47
CPC分类号： C07D217/04 , C07D401/12
摘要： The invention relates to compounds having pharmacological activity towards the 5-HT7 receptor, and more particularly to some tetrahydroisoquinoline substituted sulfonamide compounds, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which 5-HT is involved, such as CNS disorders.
摘要翻译： 本发明涉及对5-HT7受体具有药理活性的化合物，更具体地说涉及一些四氢异喹啉取代的磺酰胺化合物，这些化合物的制备方法，包含它们的药物组合物及其用于治疗和/ 涉及5-HT的疾病，如CNS疾病。
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公开(公告)号：US07078531B2
公开(公告)日：2006-07-18
申请号：US11041638
申请日：2005-01-24
IPC分类号： C07D231/12
CPC分类号： C07D409/06
摘要： A process is described for the preparation of a precursor alcohol of (±)-2-[thienyl(1-methyl-1H-pyrazol-5-yl)methoxy]-N,N-dimethyletanamine and in general for thienylazolylalcoxyethanamines and their enantiomers. The process involves asymmetric addition of a metalated thienyl reagent to a pyrazolcarbaldehyde in the presence of a chiral ligand to yield chiral alcohols. The chiral alcohols are further O-alkylated to yield the corresponding pharmaceutically active thienylazolylalcoxyethanamines.
摘要翻译： 描述了制备（±）-2- [噻吩基（1-甲基-1H-吡唑-5-基）甲氧基] -N，N-二甲基乙胺的前体醇的方法，通常用于噻吩并噻唑基醛乙氧基胺及其对映异构体。 该方法包括在手性配体的存在下将金属化噻吩试剂不对称加成到吡唑甲醛中以产生手性醇。 手性醇进一步O-烷基化，得到相应的药学活性噻吩并噻唑基乙醇胺。
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公开(公告)号：US20170112829A1
公开(公告)日：2017-04-27
申请号：US15402867
申请日：2017-01-10
申请人： José Manuel Baeyens-Cabrera , Helmut H. Buschmann , José-Miguel Vela-Hernandez , Daniel Zamanillo-Castanedo , Francisco Rafael Nieto-López
发明人： José Manuel Baeyens-Cabrera , Helmut H. Buschmann , José-Miguel Vela-Hernandez , Daniel Zamanillo-Castanedo , Francisco Rafael Nieto-López
IPC分类号： A61K31/495
CPC分类号： A61K31/495 , A61K31/137 , A61K31/40 , A61K31/445 , A61K31/4453 , A61K31/451 , A61K31/4515 , A61K31/454 , A61K31/46 , A61K31/5415
摘要： The present invention refers to the use of compounds binding to the sigma receptor for the treatment or prevention of neuropathic pain resulting from chemotherapy.
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