发明授权
US07109357B2 Process and intermediates for making substituted aspartic acid acetals
有权
制备取代天冬氨酸缩醛的方法和中间体
- 专利标题： Process and intermediates for making substituted aspartic acid acetals
- 专利标题（中）： 制备取代天冬氨酸缩醛的方法和中间体
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申请号： US10229981申请日： 2002-08-28
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公开(公告)号： US07109357B2公开(公告)日： 2006-09-19
- 发明人: Marion W. Wannamaker , Cornelia Forster
- 申请人： Marion W. Wannamaker , Cornelia Forster
- 申请人地址： US MA Cambridge
- 专利权人： Vertex Pharmaceuticals Incorporated
- 当前专利权人： Vertex Pharmaceuticals Incorporated
- 当前专利权人地址： US MA Cambridge
- 代理机构： Vertex Pharmaceuticals Incorporated
- 代理商 Lisa A. Dixon
- 主分类号： C07D307/56
- IPC分类号： C07D307/56
摘要：
Disclosed herein is a method for making compounds that are useful as caspase inhibitor prodrugs of formula I: wherein R1 is an optionally substituted group selected from an aliphatic group, aralkyl group, heterocyclylalkyl group or aryl group, and R2 is preferably a P2—P4 moiety of a caspase inhibitor. Key intermediates include the azidolactones III and VIII:
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