发明授权
- 专利标题: Process for the preparation of lipoic acid and dihydrolipoic acid
- 专利标题(中): 制备硫辛酸和二氢硫辛酸的方法
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申请号: US10432455申请日: 2001-11-29
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公开(公告)号: US07109362B2公开(公告)日: 2006-09-19
- 发明人: Martin Jochen Klatt , Markus Niebel , Joachim Paust
- 申请人: Martin Jochen Klatt , Markus Niebel , Joachim Paust
- 申请人地址: DE Ludwigshafen
- 专利权人: BASF Aktiengesellschaft
- 当前专利权人: BASF Aktiengesellschaft
- 当前专利权人地址: DE Ludwigshafen
- 代理机构: Novak, Druce & Quigg, LLP
- 优先权: DE10059718 20001130
- 国际申请: PCT/EP01/13955 WO 20011129
- 国际公布: WO02/44163 WO 20020606
- 主分类号: C07B45/00
- IPC分类号: C07B45/00 ; A61K31/095 ; C07D339/04
摘要:
The present invention relates to a process for the preparation of R- and S-lipoic acid and R- and S-dihydrolipoic acid comprising(a) reaction of where MS is SO2—R′ and R and R′ independently of one another are C1–C6-alkyl, C3–C8-cycloalkyl, C3–C8-cycloalkylalkyl, aryl or aralkyl, with sodium sulfide and sulfur in methanol. The invention especially relates to processes for preparing pure R- or S-dihydrolipoic acid, which is either used directly or processed further to give R- and S-lipoic acid. The process also serves for the production of pharmaceuticals. The present invention further relates to a solution of sodium sulfide trihydrate and sulfur in methanol, the sulfur being present in a molar excess over the sodium sulfide trihydrate, and a kit which comprises the solution according to the invention.