发明授权
- 专利标题： Polymer-modified synthetic proteins
- 专利标题（中）： 聚合物修饰的合成蛋白
-
申请号： US10332385申请日： 2001-07-12
-
公开(公告)号： US07118737B2公开(公告)日： 2006-10-10
- 发明人: Gerd G. Kochendoerfer , Paolo Botti , James A. Bradburne , Shiah-yun Chen , Sonya Cressman , Christie L. Hunter , Stephen B. H. Kent , Donald W. Low , Jill G. Wilken
- 申请人： Gerd G. Kochendoerfer , Paolo Botti , James A. Bradburne , Shiah-yun Chen , Sonya Cressman , Christie L. Hunter , Stephen B. H. Kent , Donald W. Low , Jill G. Wilken
- 申请人地址： US CA San Diego
- 专利权人： Amylin Pharmaceuticals, Inc.
- 当前专利权人： Amylin Pharmaceuticals, Inc.
- 当前专利权人地址： US CA San Diego
- 代理机构： Edell, Shapiro & Finnan, LLC
- 国际申请： PCT/US01/21930 WO 20010712
- 国际公布： WO02/20033 WO 20020314
- 主分类号： A61K38/16
- IPC分类号： A61K38/16 ; A61K38/17 ; A61K39/19 ; C07K1/113 ; C07K14/00 ; C07K14/435 ; C07K14/52
摘要：
The present invention relates to methods and compositions for modifying peptides, polypeptides and proteins with polymers, especially glyco-mimetic polymers, so as to improve their biological activity or pharmacokinetic properties. The invention further provides methods and uses for such polymer-modified peptides, polypeptides and proteins. The invention is particularly suitable for use in the synthesis of polymer-modified synthetic bioactive proteins (FIG. 1D), and of pharmaceutical compositions that contain such proteins.
公开/授权文献
- US20040115774A1 Polymer-modified synthetic proteins 公开/授权日：2004-06-17
信息查询
IPC分类:
