发明授权
- 专利标题: Macrocyclic peptides active against the hepatitis C virus
- 专利标题(中): 对丙型肝炎病毒有活性的大环肽
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申请号: US10353894申请日: 2003-01-29
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公开(公告)号: US07119072B2公开(公告)日: 2006-10-10
- 发明人: Montse Llinas-Brunet , Vida J. Gorys
- 申请人: Montse Llinas-Brunet , Vida J. Gorys
- 申请人地址: CA Laval
- 专利权人: Boehringer Ingelheim (Canada) Ltd.
- 当前专利权人: Boehringer Ingelheim (Canada) Ltd.
- 当前专利权人地址: CA Laval
- 代理商 Michael P. Morris; Mary-Ellen M. Devlin; Philip I. Datlow
- 优先权: CA2369711 20020130
- 主分类号: A61K38/00
- IPC分类号: A61K38/00
摘要:
Compounds of formula I: wherein R1 is hydroxy or NHSO2R1A wherein R1A is (C1-8)alkyl, (C3-7)cycloalkyl or {(C1-6)alkyl-(C3-7)cycloalkyl}, which are all optionally substituted from 1 to 3 times with halo, cyano, nitro, O(C1-6)alkyl, amido, amino or phenyl, or R1A is C6 or C10 aryl which is optionally substituted from 1 to 3 times with halo, cyano, nitro, (C1-6)alkyl, O(C1-6)alkyl, amido, amino or phenyl; R2 is (C5-6)cycloalkyl and R3 is cyclopentyl; or a pharmaceutically acceptable salt thereof, useful as inhibitors of the HCV NS3 protease.
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