- 专利标题： 2-oxo-1,3,4-trihydroquinazolinyl derivatives and methods of use
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申请号： US10446440申请日： 2003-05-27
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公开(公告)号： US07119111B2公开(公告)日： 2006-10-10
- 发明人: Qi Huang , Matthew Kaller , Thomas Nguyen , Mark H. Norman , Robert Rzasa , Hui-Ling Wang , Wenge Zhong
- 申请人： Qi Huang , Matthew Kaller , Thomas Nguyen , Mark H. Norman , Robert Rzasa , Hui-Ling Wang , Wenge Zhong
- 申请人地址： US CA Thousand Oaks
- 专利权人： Amgen, Inc.
- 当前专利权人： Amgen, Inc.
- 当前专利权人地址： US CA Thousand Oaks
- 代理机构： Banner & Witcoff, Ltd
- 主分类号： C07D277/60
- IPC分类号： C07D277/60 ; C07D487/00 ; A01N43/78
摘要：
Selected compounds are effective for treatment of diseases, such as cell proliferation or apoptosis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving stroke, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
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