公开(公告)号：US12233177B2

公开(公告)日：2025-02-25

申请号：US17022695

申请日：2020-09-16

Applicant: AMGEN INC.

Inventor： Wael Mismar ,  Jessica Hai Liu ,  Chia-Jung Wu ,  Shermeen A. Abbas ,  Shaun Devitt ,  Kenneth G. Schalhoub ,  Anthony Bitong ,  Mads Schjoth Due ,  Malak Guirguis ,  Rami Saifan

IPC: A61L2/20 ,  A61L2/26

Abstract: A method of externally sterilizing a drug delivery device utilizing Nitrogen Dioxide (NO2) is provided, including placing the drug delivery device in a sterilization chamber, introducing into the chamber a dose of NO2 having a concentration of between about 2 and 20 milligrams per Liter by applying a vacuum level of between about 10 and 600 Torr and holding the vacuum level for a dwell time of between about 2 and 20 minutes, repeating the step of introducing into the chamber a dose of NO2 for a number of pulses between about 1 and 24, purging the sterilization chamber of at least substantially all of the NO2, and aerating the sterilization chamber.

公开(公告)号：US20250059179A1

公开(公告)日：2025-02-20

申请号：US18696948

申请日：2022-04-28

Applicant: AMGEN INC.

Inventor： Brian Alan Lanman ,  Ryan Paul Wurz ,  Wei Zhao ,  Xiaofen Li ,  Michael M. Yamano ,  Yunxiao Li ,  Ning Chen ,  Sebastian Leth-Petersen ,  Kexue Li ,  Liping Pettus ,  Rene Rahimoff ,  Primali Vasundera Navaratne ,  Huan Rui

IPC: C07D417/14 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/5383 ,  A61K31/5386 ,  A61K31/541 ,  A61K31/55 ,  A61K31/551 ,  C07D471/04 ,  C07D471/08 ,  C07D487/04 ,  C07D487/10 ,  C07D487/20 ,  C07D498/04 ,  C07D498/10 ,  C07D519/00

Abstract: The present disclosure provides compounds useful for the inhibition of KRAS G12D. The compounds have a general Formula I: (I) wherein the variables of Formula I are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, cancer.

公开(公告)号：US20250050026A1

公开(公告)日：2025-02-13

申请号：US18931635

申请日：2024-10-30

Applicant: AMGEN INC.

Inventor： Christian PLAMBECH ,  Matias MELANDER

IPC: A61M5/20 ,  A61M5/315 ,  A61M5/32

Abstract: Injection systems for drug delivery are disclosed. A system may include a container filled or fillable with a drug, a stopper movably disposed in the container, a plunger, an energy source outputting a force, a mechanical linkage operable to transmit the force output by the energy source to the plunger to cause the plunger to act on the stopper to expel the drug from the container, and a trigger member. The system may have pre-injection state where the trigger member inhibits actuation of the mechanical linkage, an injection state where the trigger member permits actuation of the mechanical linkage, and a post-injection state where the plunger is stationarily positioned in an end-of-dose position. The system may be designed to limit the number of components included in various force transmission loops present in the pre-injection, injection, and/or post-injection states.

公开(公告)号：US12214383B2

公开(公告)日：2025-02-04

申请号：US18235419

申请日：2023-08-18

Applicant: AMGEN INC.

Inventor： Dmitry Fradkin ,  Thomas Clark Pearson ,  Neelima Chavali ,  Erwin Freund

IPC: G06N20/00 ,  B07C5/342 ,  G01N21/90 ,  G01N35/00 ,  G06T7/00

Abstract: A robotic inspection platform comprises a robotic arm, an imager, and a controller. The controller causes the robotic arm to retrieve, using its end effector, a container, and to manipulate the container such that the container is sequentially placed in a plurality of orientations while in view of the imager. The controller also causes the imager to capture images, with each of the images being captured while the container is in a respective one of the orientations. The controller also determines one or more attributes of the container, and/or a sample within the container, by analyzing the images using a pattern recognition model and, based on the attribute(s), determines whether the container and/or sample satisfies one or more criteria. If the container and/or sample fails to satisfy the criteria, the controller causes the robotic arm to place the container in an area (e.g., bin) reserved for rejected containers and/or samples.

公开(公告)号：US20250032608A1

公开(公告)日：2025-01-30

申请号：US18909660

申请日：2024-10-08

Applicant: AMGEN INC. ,  MEDIMMUNE, LLC

Inventor： Jane R. Parnes ,  Janet Griffiths

IPC: A61K39/395 ,  A61K39/00 ,  A61P11/06 ,  C07K16/24

Abstract: The present disclosure, relates, in general, to methods of treating asthma, including severe asthma and eosinophilic asthma, using an antibody specific for thymic stromal lymphopoietin (TSLP).

公开(公告)号：US20250027052A1

公开(公告)日：2025-01-23

申请号：US18778486

申请日：2024-07-19

Applicant: AMGEN INC.

Inventor： Eugenia ZAH ,  Natalia GOMEZ ,  Kristine DARIS ,  Xing MA

IPC: C12N5/071 ,  C12N9/00 ,  C12N9/06 ,  C12N15/85

Abstract: Dual vector systems, and mammalian host cells comprising them, for the expression of multi chain molecules are provided where each vector employs a different promoter driving the expression of a selectable marker. The mammalian host cells can be used for producing a recombinant protein of interest in a mammalian cell culture.

公开(公告)号：US20250018122A1

公开(公告)日：2025-01-16

申请号：US18710112

申请日：2022-11-28

Applicant: AMGEN INC.

Inventor： Ryan Oba ,  Mher Asadourian ,  Sandra Sanchez ,  Chelsea Balli-Cruz ,  Joshua Tamsky

IPC: A61M5/31 ,  G01M99/00

Abstract: A testing system for a drug delivery device includes a frame member having first and second ends, a driving member positioned near the frame member, a surrogate syringe barrel operably coupled with the frame member, a flange extender adapted to couple with a portion of the surrogate syringe barrel, and a plunger rod adapted to couple with the flange extender and be at least partially disposed within the surrogate syringe barrel while being movable therein. The driving member is movable in an axial direction between the first end and the second end of the frame member. The plunger rod includes first and second ends and a longitudinal length therebetween, the first end being positioned near a portion of the driving member. The driving member measures a maximum urging force exerted on the plunger rod when moving in the axial direction towards the second end of the frame member.

公开(公告)号：US20250017825A1

公开(公告)日：2025-01-16

申请号：US18577029

申请日：2022-06-23

Applicant: AMGEN INC.

Inventor： Todd Neslund ,  Stephen Karl Shutt ,  Eunah Choi ,  Alberto David Herrera ,  Jordan Ray Fine ,  Thomas Clark Pearson

IPC: A61J7/02 ,  G01N15/14

Abstract: A system for dispensing, inspecting, and/or processing drug includes a tray adapted to be operably coupled with a workstation, a handle member operably coupled with the tray, and a funnel region operably coupled with the tray. The tray has a body defining a recessed region and a sidewall positioned adjacent to the recessed region. The handle member is positioned at or near a first corner of the tray. The funnel region is positioned at or near a second corner of the tray. The first corner is opposite the second corner.

公开(公告)号：US12195779B2

公开(公告)日：2025-01-14

申请号：US17746008

申请日：2022-05-17

Applicant: Amgen Inc.

Inventor： Chetan Goudar ,  Sean Cole ,  Nicole Sabo ,  Henry Lin ,  Jonathan Lull ,  Tharmala Tharmalingam

IPC: C12P21/00 ,  C07K16/00 ,  C12M1/00 ,  C12M1/26 ,  C12M1/36 ,  C12N5/00

Abstract: The invention provides methods and materials for culturing mammalian cells and harvesting recombinant protein.

公开(公告)号：US12194039B2

公开(公告)日：2025-01-14

申请号：US17454592

申请日：2021-11-11

Applicant: Cytokinetics, Inc. ,  Amgen Inc.

Inventor： Narimon Honarpour ,  Fady Malik

IPC: A61K31/497 ,  A61N1/39

Abstract: Provided herein are methods of treating heart failure in patients exhibiting one or more additional features, comprising administering to the patient a therapeutically effective amount of omecamtiv mecarbil, or a hydrate, salt, or salt of a hydrate thereof.