发明授权
US07122536B2 (R)-chiral halogenated substituted fused heterocyclic amino compounds useful for inhibiting cholesterol ester transfer protein activity
失效
（R） - 用于抑制胆固醇酯转移蛋白活性的卤代取代稠合杂环氨基化合物
- 专利标题： (R)-chiral halogenated substituted fused heterocyclic amino compounds useful for inhibiting cholesterol ester transfer protein activity
- 专利标题（中）： （R） - 用于抑制胆固醇酯转移蛋白活性的卤代取代稠合杂环氨基化合物
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申请号： US10929013申请日： 2004-08-27
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公开(公告)号： US07122536B2公开(公告)日： 2006-10-17
- 发明人: James A. Sikorski , Richard C. Durley , Margaret L. Grapperhaus , Mark A. Massa , Emily J. Reinhard , Yvette M. Fobian , Michael B. Tollefson , Lijuan Wang , Brian S. Hickory , Monica B. Norton , William F. Vernier , Deborah A. Mischke , Michele A. Promo , Ashton T. Hamme , Dale P. Spangler , Melvin L. Rueppel
- 申请人： James A. Sikorski , Richard C. Durley , Margaret L. Grapperhaus , Mark A. Massa , Emily J. Reinhard , Yvette M. Fobian , Michael B. Tollefson , Lijuan Wang , Brian S. Hickory , Monica B. Norton , William F. Vernier , Deborah A. Mischke , Michele A. Promo , Ashton T. Hamme , Dale P. Spangler , Melvin L. Rueppel
- 申请人地址： US NY New York
- 专利权人： Pfizer Inc.
- 当前专利权人： Pfizer Inc.
- 当前专利权人地址： US NY New York
- 代理商 Gregg C. Benson; Lisa A. Samuels
- 主分类号： A61K31/33
- IPC分类号： A61K31/33 ; A61K31/557 ; A61K31/535
摘要：
The invention relates to substituted aryl and heteroaryl (R)-Chiral Halogenated 1-Substitutedamino-(n+1)-Alkanol compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other coronary artery diseases. Novel high yield, stereoselective processes for the preparation of the chiral substituted alkanol compounds from chiral and achiral intermediates are described.
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