发明授权
- 专利标题: NK1 antagonists
- 专利标题(中): NK1拮抗剂
-
申请号: US10292618申请日: 2002-11-12
-
公开(公告)号: US07122677B2公开(公告)日: 2006-10-17
- 发明人: Gregory A. Reichard , Sunil Paliwal , Neng-Yang Shih , Dong Xiao , Hon-Chung Tsui , Sapna Majmundar Shah , Cheng Wang , Michelle Laci Wrobleski
- 申请人: Gregory A. Reichard , Sunil Paliwal , Neng-Yang Shih , Dong Xiao , Hon-Chung Tsui , Sapna Majmundar Shah , Cheng Wang , Michelle Laci Wrobleski
- 申请人地址: US NJ Kenilworth
- 专利权人: Scherig Corporation
- 当前专利权人: Scherig Corporation
- 当前专利权人地址: US NJ Kenilworth
- 代理商 Serena Farquharson-Torres
- 主分类号: C07D207/00
- IPC分类号: C07D207/00 ; C07D209/96 ; C07D225/00 ; C07D215/00 ; A01N57/00
摘要:
A NK1 antagonist having the formula (I), wherein Ar1 and Ar2 are optionally substituted phenyl or heteroaryl, X1 is an ether, thio or imino linkage, R4 and R5 are not both H or alkyl, and the remaining variables are as defined in the in the specification, useful for treating a number of disorders, including emesis, depression, anxiety and cough. Pharmaceuticals compositions. Methods of treatment and combinations with other agents are also disclosed.
公开/授权文献
- US20030144270A1 NK1 antagonists 公开/授权日:2003-07-31
信息查询