公开(公告)号：US07122677B2

公开(公告)日：2006-10-17

申请号：US10292618

申请日：2002-11-12

申请人： Gregory A. Reichard ,  Sunil Paliwal ,  Neng-Yang Shih ,  Dong Xiao ,  Hon-Chung Tsui ,  Sapna Majmundar Shah ,  Cheng Wang ,  Michelle Laci Wrobleski

发明人： Gregory A. Reichard ,  Sunil Paliwal ,  Neng-Yang Shih ,  Dong Xiao ,  Hon-Chung Tsui ,  Sapna Majmundar Shah ,  Cheng Wang ,  Michelle Laci Wrobleski

IPC分类号： C07D207/00 ,  C07D209/96 ,  C07D225/00 ,  C07D215/00 ,  A01N57/00

CPC分类号： C07D207/26 ,  C07D207/273 ,  C07D207/38 ,  C07D401/04

摘要： A NK1 antagonist having the formula (I), wherein Ar1 and Ar2 are optionally substituted phenyl or heteroaryl, X1 is an ether, thio or imino linkage, R4 and R5 are not both H or alkyl, and the remaining variables are as defined in the in the specification, useful for treating a number of disorders, including emesis, depression, anxiety and cough. Pharmaceuticals compositions. Methods of treatment and combinations with other agents are also disclosed.

摘要翻译： 具有式（I）的NK 1拮抗剂，其中Ar 1和Ar 2是任选取代的苯基或杂芳基，X 1 硫醚或亚氨基连接，R 4和R 5不都是H或烷基，而其余的变量如 规范，用于治疗许多疾病，包括呕吐，抑郁，焦虑和咳嗽。 药物组合物。 还公开了治疗方法和与其它药剂的组合。