发明授权
US07125854B2 Bicyclic carbohydrates as antiprotozoal bioactive for the treatment of infections caused by parasites
失效
双环碳水化合物作为抗原生物活性物质用于治疗由寄生虫引起的感染
- 专利标题: Bicyclic carbohydrates as antiprotozoal bioactive for the treatment of infections caused by parasites
- 专利标题(中): 双环碳水化合物作为抗原生物活性物质用于治疗由寄生虫引起的感染
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申请号: US10752792申请日: 2004-01-07
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公开(公告)号: US07125854B2公开(公告)日: 2006-10-24
- 发明人: Benedikt Sas , Johan Van hemel , Jan Vandenkerckhove , Eric Peys , Johan Van der Eycken , Bart Ruttens
- 申请人: Benedikt Sas , Johan Van hemel , Jan Vandenkerckhove , Eric Peys , Johan Van der Eycken , Bart Ruttens
- 申请人地址: US IA Des Moines
- 专利权人: Kemin Pharma B.V.B.A.
- 当前专利权人: Kemin Pharma B.V.B.A.
- 当前专利权人地址: US IA Des Moines
- 代理商 Kent A. Herink; Daniel A. Rosenberg; Emily E. Harris
- 主分类号: A01N43/04
- IPC分类号: A01N43/04 ; A01N43/16 ; A61K31/70 ; A61K31/35
摘要:
The use of bicyclic carbohydrates for the treatment of parasite infections is described. Different bicyclic carbohydrates have been tested in vitro against a number of protozoa. These compounds also have been screened against viruses, tumors, bacteria and fungi. Compound A1, a thiophenyl-containing bicyclic carbohydrate possessed significant activity against Trypanosoma brucei rhodiense, a parasite that causes the lethal sleeping sickness. Compound A2 and Compound A3, bicyclic carbohydrates with halogen containing aryl groups, possessed significant activity against Leishmania donovani, a parasite that causes leishmaniasis. Bicyclic carbohydrates in general, and Compound A1, Compound A2 and Compound A3 more specifically, could be possible treatments for the sleeping sickness and leishmaniasis in the future.