Use of endoperoxides for the treatment of infections caused by flaviviridae, including hepatitis C, bovine viral diarrhea and classical swine fever virus
    2.
    发明授权
    Use of endoperoxides for the treatment of infections caused by flaviviridae, including hepatitis C, bovine viral diarrhea and classical swine fever virus 失效
    使用内过氧化物治疗由黄病毒引起的感染,包括丙型肝炎,牛病毒性腹泻和古典猪瘟病毒

    公开(公告)号:US07842719B2

    公开(公告)日:2010-11-30

    申请号:US10664008

    申请日:2003-09-16

    IPC分类号: A61K31/335 A61K38/00

    摘要: The use of sesquiterpenes and, in particular sesquiterpene lactone endoperoxides, such as artemisinin and analogs thereof, for the treatment of hepatitis C virus infections. Artemisinin, analogs of artemsisnin and some crude Artemisia extracts were tested in vitro against DNA-viruses, retro-viruses and Flavivirida, (an important family of human and animal RNA pathogens). These compounds were also screened for anti-tumor activity. Strong activity of artemisinin was noticed against the bovine viral diarrhea virus (BVDV). As pestiviruses, such as BVDV, share many similarities with hepatitis C virus (HCV), we can conclude that endoperoxides in general and artemisinin more specifically have efficacy as treatments for hepatitis C viral infections.

    摘要翻译: 使用倍半萜烯,特别是倍半萜内酯内过氧化物,如青蒿素及其类似物,用于治疗丙型肝炎病毒感染。 在体外对DNA病毒,逆转录病毒和黄病毒(人类和动物RNA病原体的重要家族)进行体外测定青蒿素,青蒿素类似物和一些粗蒿提取物。 也筛选了这些化合物的抗肿瘤活性。 注意到青蒿素对牛病毒性腹泻病毒(BVDV)的活性较强。 作为瘟病毒,如BVDV,与丙型肝炎病毒(HCV)有许多相似之处,我们可以得出结论,一般的过氧化物和青蒿素更具体地具有治疗丙型肝炎病毒感染的功效。

    Method for the conversion of lecithin into lysolecithin
    6.
    发明授权
    Method for the conversion of lecithin into lysolecithin 有权
    卵磷脂转化为溶血卵磷脂的方法

    公开(公告)号:US6068997A

    公开(公告)日:2000-05-30

    申请号:US259603

    申请日:1999-03-01

    IPC分类号: C12P7/64 C12P13/00

    CPC分类号: C12P7/6445 C12P13/00

    摘要: Conversion of crude lecithin is performed by incubating the lecithin with a lipase-phospholipase mixture in a water/polyol environment. The incubation is carried out at about 40-50.degree. C. and a pH of about 7 to about 8 while stirring continuously. The reaction simultaneously produces lysolipid, lysophospholipid, monoglycerides, and diglycerides. The conversion rate of lecithin is more than 80% based on the ratio of LPC/PC (lysophosphatidylcholine/phosphatidylcholine). Calcium chloride can be added to the reaction mixture to capture released fatty acids.

    摘要翻译: 通过在水/多元醇环境中将卵磷脂与脂肪酶 - 磷脂酶混合物孵育来进行粗卵磷脂的转化。 在约40-50℃下进行温育并在约7至约8的pH下连续搅拌。 反应物同时产生溶脂,溶血磷脂,甘油单酯和甘油二酯。 基于LPC / PC(溶血磷脂酰胆碱/磷脂酰胆碱)的比例,卵磷脂的转化率大于80%。 可以将氯化钙加入到反应混合物中以捕获释放的脂肪酸。

    Method for improving the activity of enzymes
    10.
    发明授权
    Method for improving the activity of enzymes 有权
    提高酶活性的方法

    公开(公告)号:US07211281B2

    公开(公告)日:2007-05-01

    申请号:US09753381

    申请日:2001-01-02

    IPC分类号: A23K1/14 A23K1/165

    摘要: A method for improving the performance of enzymes used in animal feeds by the use of surfactants. Lecithin and/or lysolecithin is added to an animal feed including an exogenous enzyme to boost the performance of the enzyme so that a desired level of performance can be maintained while reducing the amount of exogenous enzyme that must be included in the animal feed. Preferably, the surfactant includes lyso-forms of lecithin.

    摘要翻译: 一种通过使用表面活性剂改善动物饲料中所用酶的性能的方法。 将卵磷脂和/或溶血卵磷脂加入到包含外源酶的动物饲料中以增强酶的性能,使得可以在减少必须包括在动物饲料中的外源酶的量的同时保持期望的水平。 优选地,表面活性剂包括卵磷脂的溶解形式。