发明授权
- 专利标题： Tripeptide and tetrapeptide thioethers
- 专利标题（中）： 三肽和四肽硫醚
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申请号： US11325846申请日： 2006-01-04
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公开(公告)号： US07129215B2公开(公告)日： 2006-10-31
- 发明人: Natalia Aurrecoechea , Andrew B. Kelson , Robert W. Macsata , Louise Robinson , Anthony J. Sanchez , Nicholas M. Santiago , Steven R. Schow , Reyna J. Simon
- 申请人： Natalia Aurrecoechea , Andrew B. Kelson , Robert W. Macsata , Louise Robinson , Anthony J. Sanchez , Nicholas M. Santiago , Steven R. Schow , Reyna J. Simon
- 申请人地址： US CA Palo Alto
- 专利权人： Telik, Inc.
- 当前专利权人： Telik, Inc.
- 当前专利权人地址： US CA Palo Alto
- 代理机构： Foley & Lardner LLP
- 主分类号： A61K38/05
- IPC分类号： A61K38/05 ; A61K38/06 ; C07K5/02
摘要：
Tripeptide and tetrapeptide thioethers, pharmaceutical compositions containing them, their pharmaceutical use, and their preparation. The compounds are useful in potentiating the cytotoxic effects of chemotherapeutic agents in tumor cells, selectively exerting toxicity in tumor cells, elevating the production of GM progenitors in bone marrow, stimulating the differentiation of bone marrow, mitigating the myelosuppressive effects of chemotherapeutic agents, and modulating hematopoiesis in bone marrow.
公开/授权文献
- US20060160749A1 TRIPEPTIDE AND TETRAPEPTIDE THIOETHERS 公开/授权日：2006-07-20
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