-
公开(公告)号：US20090126932A1
公开(公告)日：2009-05-21
申请号：US12238107
申请日：2008-09-25
申请人： Kay Louise Robinson , Maria Violante De Paz Banez , Gary John Tustin , Timothy Gareth John Jones
发明人： Kay Louise Robinson , Maria Violante De Paz Banez , Gary John Tustin , Timothy Gareth John Jones
IPC分类号： E21B43/00 , C07D491/18 , C07D307/34 , E21B43/26 , E21B43/04 , C08F218/00 , E21B43/22
CPC分类号： C08F220/28 , C08F220/56 , C08F220/58 , C08F222/40
摘要： This invention relates to the synthesis and use in oilfield applications of copolymers which can undergo the Diels-Alder reaction to form a gel. Under appropriate conditions, the retro Diels-Alder reaction can take place to provide for decreasing the viscosity of the aforementioned gel.
摘要翻译： 本发明涉及可以经历Diels-Alder反应形成凝胶的共聚物的油田应用中的合成和应用。 在适当的条件下，可以进行复古Diels-Alder反应以提供降低上述凝胶的粘度。
-
公开(公告)号：US07297696B2
公开(公告)日：2007-11-20
申请号：US10969440
申请日：2004-10-19
申请人： Edgardo Laborde , Louise Robinson , Fanying Meng , Brian T. Peterson , Hugo O. Villar , Steven E. Anuskiewicz , Yoshiro Ishiwata , Shoji Yokochi , Yukiharu Matsumoto , Takuji Kakigami , Hideaki Inagaki , Takahito Jomori , Kouji Matsushima
发明人： Edgardo Laborde , Louise Robinson , Fanying Meng , Brian T. Peterson , Hugo O. Villar , Steven E. Anuskiewicz , Yoshiro Ishiwata , Shoji Yokochi , Yukiharu Matsumoto , Takuji Kakigami , Hideaki Inagaki , Takahito Jomori , Kouji Matsushima
IPC分类号： A61K31/498 , C07D241/36
CPC分类号： C07D401/12 , C07D215/48 , C07D241/42 , C07D265/36 , C07D319/18 , C07D405/12 , C07D407/12 , C07D409/12 , C07D417/12
摘要： Compounds which are antagonists of MCP-1 function and are useful in the prevention or treatment of chronic or acute inflammatory or autoimmune diseases, especially those associated with aberrant lymphocyte or monocyte accumulation such as arthritis, asthma, atherosclerosis, diabetic nephropathy, inflammatory bowel disease, Crohn's disease, multiple sclerosis, nephrtitis, pancreatitis, pulmonary fibrosis, psoriasis, restenosis, and transplant rejection; pharmaceutical compositions comprising these compounds; and the use of these compounds and compositions in the prevention or treatment of such diseases.
摘要翻译： 作为MCP-1拮抗剂的化合物起作用，可用于预防或治疗慢性或急性炎性或自身免疫性疾病，特别是与异常淋巴细胞或单核细胞积累相关的疾病如关节炎，哮喘，动脉粥样硬化，糖尿病性肾病，炎性肠病， 克罗恩病，多发性硬化，肾炎，胰腺炎，肺纤维化，牛皮癣，再狭窄和移植排斥反应; 包含这些化合物的药物组合物; 以及这些化合物和组合物在预防或治疗这些疾病中的用途。
-
公开(公告)号：US07262182B2
公开(公告)日：2007-08-28
申请号：US11134218
申请日：2005-05-20
申请人： Louise Robinson , Steven R. Schow , Songyuan Shi
发明人： Louise Robinson , Steven R. Schow , Songyuan Shi
CPC分类号： C07F9/2458 , C07F9/2408 , C07F9/572 , C07F9/58 , C07F9/59 , C07F9/650952 , C07F9/6533 , C07F9/65515 , C07F9/655345 , C07F9/65616
摘要： Sulfonylethyl and thioethyl phosphorodiamidates, their preparation and intermediates in their preparation, formulations containing them, and their pharmaceutical use. The compounds are useful for treating cancer, alone and in combination with other anticancer therapies.
摘要翻译： 磺基乙基和硫代乙基磷酰二胺，它们的制备和中间体在制备中，含有它们的制剂及其药物用途。 该化合物可用于单独治疗和与其它抗癌疗法组合治疗癌症。
-
公开(公告)号：US20050054668A1
公开(公告)日：2005-03-10
申请号：US10969440
申请日：2004-10-19
申请人： Edgardo Laborde , Louise Robinson , Fanying Meng , Brian Peterson , Hugo Villar , Steven Anuskiewicz , Yoshiro Ishiwata , Shoji Yokochi , Yukiharu Matsumoto , Takuji Kakigami , Hideaki Inagaki , Takahito Jomori , Kouji Matsushima
发明人： Edgardo Laborde , Louise Robinson , Fanying Meng , Brian Peterson , Hugo Villar , Steven Anuskiewicz , Yoshiro Ishiwata , Shoji Yokochi , Yukiharu Matsumoto , Takuji Kakigami , Hideaki Inagaki , Takahito Jomori , Kouji Matsushima
IPC分类号： A61K31/357 , A61K31/41 , A61K31/427 , A61K31/4433 , A61K31/47 , A61K31/498 , A61K31/538 , A61K45/00 , A61P1/04 , A61P1/18 , A61P3/10 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P29/00 , A61P37/00 , A61P37/02 , A61P37/08 , A61P43/00 , C07D215/48 , C07D241/42 , C07D241/44 , C07D265/36 , C07D319/18 , C07D401/12 , C07D405/12 , C07D407/12 , C07D409/12 , C07D417/12 , C07D491/02 , A61K31/4745 , C07D471/02 , C07D498/02
CPC分类号： C07D401/12 , C07D215/48 , C07D241/42 , C07D265/36 , C07D319/18 , C07D405/12 , C07D407/12 , C07D409/12 , C07D417/12
摘要： Compounds which are antagonists of MCP-1 function and are useful in the prevention or treatment of chronic or acute inflammatory or autoimmune diseases, especially those associated with aberrant lymphocyte or monocyte accumulation such as arthritis, asthma, atherosclerosis, diabetic nephropathy, inflammatory bowel disease, Crohn's disease, multiple sclerosis, nephrtitis, pancreatitis, pulmonary fibrosis, psoriasis, restenosis, and transplant rejection; pharmaceutical compositions comprising these compounds; and the use of these compounds and compositions in the prevention or treatment of such diseases.
摘要翻译： 作为MCP-1拮抗剂的化合物起作用，可用于预防或治疗慢性或急性炎性或自身免疫性疾病，特别是与异常淋巴细胞或单核细胞积累相关的疾病如关节炎，哮喘，动脉粥样硬化，糖尿病性肾病，炎性肠病， 克罗恩病，多发性硬化，肾炎，胰腺炎，肺纤维化，牛皮癣，再狭窄和移植排斥反应; 包含这些化合物的药物组合物; 以及这些化合物和组合物在预防或治疗这些疾病中的用途。
-
公开(公告)号：US06670364B2
公开(公告)日：2003-12-30
申请号：US10060967
申请日：2002-01-29
申请人： Edgardo Laborde , Louise Robinson , Fanying Meng , Brian T. Peterson , Hugo O. Villar , Steven E. Anuskiewicz , Yoshiro Ishiwata , Shoji Yokochi , Yukiharu Matsumoto , Takuji Kakigami , Hideaki Inagaki , Takahito Jomori , Kouji Matsushima
发明人： Edgardo Laborde , Louise Robinson , Fanying Meng , Brian T. Peterson , Hugo O. Villar , Steven E. Anuskiewicz , Yoshiro Ishiwata , Shoji Yokochi , Yukiharu Matsumoto , Takuji Kakigami , Hideaki Inagaki , Takahito Jomori , Kouji Matsushima
IPC分类号： A61P2900
CPC分类号： C07D471/04 , A61K31/437 , A61K31/496 , A61K31/5377 , A61K31/5513 , A61K45/06 , A61K2300/00
摘要： The present invention relates to chemical compounds, pharmaceutical compositions comprising said compounds, uses of said compounds and compositions, methods of treatment employing said compounds and compositions, and processes for preparing said compounds. Specifically, this invention relates to novel compounds which are antagonists of MCP-1 function and are useful in the prevention or treatment of chronic or acute inflammatory or autoimmune diseases, especially those associated with aberrant lymphocyte or monocyte accumulation such as arthritis, asthma, atherosclerosis, diabetic nephropathy, inflammatory bowel disease, Crohn's disease, multiple sclerosis, nephritis, pancreatitis, pulmonary fibrosis, psoriasis, restenosis, and transplant rejection. More specifically, the invention is related to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases.
摘要翻译： 本发明涉及化合物，包含所述化合物的药物组合物，所述化合物和组合物的用途，使用所述化合物和组合物的治疗方法，以及制备所述化合物的方法。 具体而言，本发明涉及作为MCP-1功能的拮抗剂的新化合物，其可用于预防或治疗慢性或急性炎性或自身免疫性疾病，特别是与异常淋巴细胞或单核细胞积累相关的疾病，例如关节炎，哮喘，动脉粥样硬化， 糖尿病肾病，炎性肠病，克罗恩病，多发性硬化，肾炎，胰腺炎，肺纤维化，牛皮癣，再狭窄和移植排斥反应。 更具体地，本发明涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗这些疾病中的用途。
-
公开(公告)号：US07987912B2
公开(公告)日：2011-08-02
申请号：US12238107
申请日：2008-09-25
申请人： Kay Louise Robinson , Maria Violante De Paz Banez , Gary John Tustin , Timothy Gareth John Jones
发明人： Kay Louise Robinson , Maria Violante De Paz Banez , Gary John Tustin , Timothy Gareth John Jones
CPC分类号： C08F220/28 , C08F220/56 , C08F220/58 , C08F222/40
摘要： A subterranean location accessed via a wellbore is treated with an oilfield fluid containing a viscosifying agent which is a polymer and a cross-linking agent which can undergo the Diels-Alder reaction to form a gel. Conditions at the subterranean location alter fluid viscosity by bringing about the Diels-Alder reaction to increase viscosity or the retro Diels-Alder reaction to decrease the viscosity of the gel.
摘要翻译： 通过井眼访问的地下位置用含有增粘剂的油田液体进行处理，所述增稠剂是可以经历Diels-Alder反应以形成凝胶的聚合物和交联剂。 地下位置的条件通过使Diels-Alder反应增加粘度或者减少Diels-Alder反应来降低凝胶粘度来改变流体粘度。
-
公开(公告)号：US20060160749A1
公开(公告)日：2006-07-20
申请号：US11325846
申请日：2006-01-04
申请人： Natalia Aurrecoechea , Andrew Kelson , Robert Macsata , Louise Robinson , Anthony Sanchez , Nicholas Santiago , Steven Schow , Reyna Simon
发明人： Natalia Aurrecoechea , Andrew Kelson , Robert Macsata , Louise Robinson , Anthony Sanchez , Nicholas Santiago , Steven Schow , Reyna Simon
CPC分类号： C07K5/0215 , A61K38/00
摘要： Tripeptide and tetrapeptide thioethers, pharmaceutical compositions containing them, their pharmaceutical use, and their preparation. The compounds are useful in potentiating the cytotoxic effects of chemotherapeutic agents in tumor cells, selectively exerting toxicity in tumor cells, elevating the production of GM progenitors in bone marrow, stimulating the differentiation of bone marrow, mitigating the myelosuppressive effects of chemotherapeutic agents, and modulating hematopoiesis in bone marrow.
摘要翻译： 三肽和四肽硫醚，含有它们的药物组合物，它们的药物用途及其制备。 该化合物可用于增强化疗药物在肿瘤细胞中的细胞毒性作用，选择性地在肿瘤细胞中发挥毒性，提高骨髓中转基因祖细胞的产生，刺激骨髓分化，减轻化疗药物的骨髓抑制作用，以及调节 骨髓造血。
-
公开(公告)号：US06998407B2
公开(公告)日：2006-02-14
申请号：US10716652
申请日：2003-11-18
申请人： Edgardo Laborde , Louise Robinson , Fanying Meng , Brian T. Peterson , Hugo O. Villar , Steven E. Anuskiewicz , Yoshiro Ishiwata , Shoji Yokochi , Yukiharu Matsumoto , Takuji Kakigami , Hideaki Inagaki , Takahito Jomori , Kouji Matsushima
发明人： Edgardo Laborde , Louise Robinson , Fanying Meng , Brian T. Peterson , Hugo O. Villar , Steven E. Anuskiewicz , Yoshiro Ishiwata , Shoji Yokochi , Yukiharu Matsumoto , Takuji Kakigami , Hideaki Inagaki , Takahito Jomori , Kouji Matsushima
IPC分类号： A61K31/36 , A61K31/343 , C07D307/79 , C07D317/60
CPC分类号： C07D235/06 , C07D209/08 , C07D249/18 , C07D263/56 , C07D307/79 , C07D317/68 , C07D405/12 , C07D407/12 , C07D409/12 , C07D417/12
摘要： Chemical compounds which are antagonists of Monocyte Chemoattractant Protein-1 (MCP-1) function, pharmaceutical compositions comprising these compounds, methods of treatment employing these compounds and compositions, and processes for preparing these compounds. The compounds are useful in the prevention or treatment of chronic or acute inflammatory or autoimmune diseases, especially those associated with aberrant lymphocyte or monocyte accumulation such as arthritis, asthma, atherosclerosis, diabetic nephropathy, inflammatory bowel disease, Crohn's disease, multiple sclerosis, nephritis, pancreatitis, pulmonary fibrosis, psoriasis, restenosis, and transplant rejection.
摘要翻译： 作为单核细胞趋化蛋白-1（MCP-1）功能拮抗剂的化合物，包含这些化合物的药物组合物，使用这些化合物和组合物的治疗方法，以及制备这些化合物的方法。 该化合物可用于预防或治疗慢性或急性炎性或自身免疫疾病，特别是与异常淋巴细胞或单核细胞积累相关的疾病，如关节炎，哮喘，动脉粥样硬化，糖尿病性肾病，炎性肠病，克罗恩病，多发性硬化，肾炎， 胰腺炎，肺纤维化，牛皮癣，再狭窄和移植排斥。
-
公开(公告)号：US06992086B2
公开(公告)日：2006-01-31
申请号：US10716363
申请日：2003-11-17
申请人： Edgardo Laborde , Louise Robinson , Fanying Meng , Brian T. Peterson , Hugo O. Villar , Steven E. Anuskiewicz , Yoshiro Ishiwata , Shoji Yokochi , Yukiharu Matsumoto , Takuji Kakigami , Hideaki Inagaki , Takahito Jomori , Kouji Matsushima
发明人： Edgardo Laborde , Louise Robinson , Fanying Meng , Brian T. Peterson , Hugo O. Villar , Steven E. Anuskiewicz , Yoshiro Ishiwata , Shoji Yokochi , Yukiharu Matsumoto , Takuji Kakigami , Hideaki Inagaki , Takahito Jomori , Kouji Matsushima
IPC分类号： A61K31/496 , A61K31/437 , C07D498/04 , C07D471/04 , A61P37/00
CPC分类号： C07D471/04 , A61K31/437 , A61K31/496 , A61K31/5377 , A61K31/5513 , A61K45/06 , A61K2300/00
摘要： The present invention relates to chemical compounds, pharmaceutical compositions comprising said compounds, uses of said compounds and compositions, methods of treatment employing said compounds and compositions, and processes for preparing said compounds. Specifically, this invention relates to novel compounds which are antagonists of MCP-1 function and are useful in the prevention or treatment of chronic or acute inflammatory or autoimmune diseases, especially those associated with aberrant lymphocyte or monocyte accumulation such as arthritis, asthma, atherosclerosis, diabetic nephropathy, inflammatory bowel disease, Crohn's disease, multiple sclerosis, nephritis, pancreatitis, pulmonary fibrosis, psoriasis, restenosis, and transplant rejection. More specifically, the invention is related to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases.
-
公开(公告)号：US06677365B2
公开(公告)日：2004-01-13
申请号：US10106881
申请日：2002-03-25
申请人： Edgardo Laborde , Louise Robinson , Fanying Meng , Brian T. Peterson , Hugo O. Villar , Steven E. Anuskiewicz , Yoshiro Ishiwata , Shoji Yokochi , Yukiharu Matsumoto , Takuji Kakigami , Hideaki Inagaki , Takahito Jomori , Kouji Matsushima
发明人： Edgardo Laborde , Louise Robinson , Fanying Meng , Brian T. Peterson , Hugo O. Villar , Steven E. Anuskiewicz , Yoshiro Ishiwata , Shoji Yokochi , Yukiharu Matsumoto , Takuji Kakigami , Hideaki Inagaki , Takahito Jomori , Kouji Matsushima
IPC分类号： A61K3142
CPC分类号： C07D235/06 , C07D209/08 , C07D249/18 , C07D263/56 , C07D307/79 , C07D317/68 , C07D405/12 , C07D407/12 , C07D409/12 , C07D417/12
摘要： Chemical compounds which are antagonists of Monocyte Chemoattractant Protein-1 (MCP-1) function, pharmaceutical compositions comprising these compounds, methods of treatment employing these compounds and compositions, and processes for preparing these compounds. The compounds are useful in the prevention or treatment of chronic or acute inflammatory or autoimmune diseases, especially those associated with aberrant lymphocyte or monocyte accumulation such as arthritis, asthma, atherosclerosis, diabetic nephropathy, inflammatory bowel disease, Crohn's disease, multiple sclerosis, nephritis, pancreatitis, pulmonary fibrosis, psoriasis, restenosis, and transplant rejection.
-
-
-
-
-
-
-
-
-
搜索结果
22 条记录 (耗时 0.027 秒)
