发明授权
US07129223B2 Inhibition of SARS-associated coronavirus (SCoV) infection and replication by RNA interference
有权
通过RNA干扰抑制SARS相关冠状病毒（SCoV）感染和复制
- 专利标题： Inhibition of SARS-associated coronavirus (SCoV) infection and replication by RNA interference
- 专利标题（中）： 通过RNA干扰抑制SARS相关冠状病毒（SCoV）感染和复制
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申请号： US10848737申请日： 2004-05-19
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公开(公告)号： US07129223B2公开(公告)日： 2006-10-31
- 发明人: Hsiang-Fu Kung , Ming-Liang He , Bo-Jiang Zheng , Yi Guan , Marie Chia-Mi Lin , Ying Peng
- 申请人： Hsiang-Fu Kung , Ming-Liang He , Bo-Jiang Zheng , Yi Guan , Marie Chia-Mi Lin , Ying Peng
- 申请人地址： CN
- 专利权人： The University of HongKong
- 当前专利权人： The University of HongKong
- 当前专利权人地址： CN
- 代理机构： Dickstein, Shapiro, LLP.
- 主分类号： A61K31/7088
- IPC分类号： A61K31/7088 ; C07H21/04 ; C12N5/10 ; C12N15/50 ; C12N15/63
摘要：
The present invention relates to therapeutic agents useful for the treatment of Severe Acute Respiratory Syndrome (SARS) in humans. In particular, the present invention relates to RNA interference (RNAi) molecules useful for inhibiting the infection and replication of hSARS virus. Preferably, the RNAi molecules target the replicase region of the hSARS virus, or combinations of different sites of hSARS virus genes. The present invention further encompasses methods of using the RNAi molecules for preventing and/or treating SARS. Vaccines and kits comprising therapeutically effective amounts of the RNAi molecules are also encompassed.
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