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发明授权
US07135333B1 Compositions that specifically bind to colorectal cancer cells and methods of using the same 有权
特异性结合结肠直肠癌细胞的组合物及其使用方法

Compositions that specifically bind to colorectal cancer cells and methods of using the same
摘要：
A unique transcription product, CRCA-1, and alternative translation products generated therefrom, are disclosed. The transcript and its translation products are markers for colorectal cells. Screening and diagnostic reagents, kits and methods for metastasized colorectal cancer are disclosed as are reagents, kits and methods for identifying adenocarcinomas as colorectal in origin. Compounds, compositions and methods of treating patients with metastasized colorectal cancer and for imaging metastasized colorectal tumors in vivo are disclosed. Compositions and methods for delivering active compounds such as gene therapeutics and antisense compounds to colorectal cells are disclosed. Vaccines compositions and methods of for treating and preventing metastasized colorectal cancer are disclosed.
摘要（中）：

公开了一种独特的转录产物CRCA-1和由其产生的替代的翻译产物。 转录物及其翻译产物是结肠直肠细胞的标志物。 公开了用于转移性结直肠癌的筛选和诊断试剂，试剂盒和方法，作为用于鉴定起源于结肠直肠的腺癌的试剂，试剂盒和方法。 公开了治疗转移性结肠直肠癌患者和体内成像转移性结肠直肠肿瘤的化合物，组合物和方法。 公开了将结合活性化合物如基因治疗剂和反义化合物递送至结肠直肠细胞的组合物和方法。 公开了用于治疗和预防转移性结肠直肠癌的疫苗组合物和方法。

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