公开(公告)号：US20160192948A1

公开(公告)日：2016-07-07

申请号：US14917135

申请日：2014-09-06

Applicant: THOMAS JEFFERSON UNIVERSITY ,  THOMAS JEFFERSON UNIVERSITY HOSPITAL, INC.

Inventor： Chengyuan WU ,  Ashwini D. SHARAN

IPC: A61B17/16 ,  A61B17/68

CPC classification number: A61B17/1695 ,  A61B17/1622 ,  A61B17/688

Abstract: In accordance with one embodiment, a device for performing an angled craniotome includes an elongate handle, a footplate, a stem, and an elongate cutting bit. The elongate handle extends in a vertical direction. The footplate is spaced apart from the elongate handle and defines a plane generally perpendicular to the vertical direction. The footplate is offset from the handle in a horizontal direction where the horizontal direction is perpendicular to the vertical direction. The stem has a proximal end and a distal end. The proximal end is coupled to the handle and the distal end is coupled to the footplate. The stem extends from the handle at an oblique angle in the horizontal direction relative to the handle. The elongate cutting bit is coupled to the handle and extends from the handle toward the footplate at the oblique angle in the horizontal direction relative to the handle.

Abstract translation: 根据一个实施例，用于执行倾斜开颅器的装置包括细长手柄，脚踏板，杆和细长切割钻头。 细长手柄在垂直方向上延伸。 脚板与细长手柄间隔开，并且限定了一个垂直于垂直方向的平面。 脚板在水平方向垂直于垂直方向的水平方向上从手柄偏移。 茎具有近端和远端。 近端联接到手柄，并且远端联接到脚踏板。 杆从手柄以相对于把手的水平方向倾斜的角度延伸。 细长切割钻头联接到手柄并且在手柄朝向底板的相对于手柄的水平方向上以倾斜角度延伸。

公开(公告)号：US20140255518A1

公开(公告)日：2014-09-11

申请号：US14114727

申请日：2012-04-27

Applicant: Peng Li ,  Scott A. Waldman ,  Evan Wuthrick

Inventor： Peng Li ,  Scott A. Waldman ,  Evan Wuthrick

IPC: C07K14/58 ,  C07K14/575 ,  A61K45/06 ,  A61K38/22

CPC classification number: C07K14/58 ,  A61K38/10 ,  A61K38/16 ,  A61K38/22 ,  A61K38/2242 ,  A61K45/06 ,  C07K14/575

Abstract: Compositions comprising a guanylyl cyclase C agonist in an amount effective to protect intestinal tissue against radiation or chemotherapy and methods of using such compositions to prevent GI syndrome in cancer patient undergoing radiation or chemotherapy and in individuals exposed to or susceptible to exposure to radiation are disclosed.

Abstract translation: 公开了包含有效保护肠组织免受辐射或化学疗法的量的鸟苷酸环化酶C激动剂的组合物和使用这些组合物来预防接受放射或化疗的癌症患者中的GI综合征以及暴露于或易于暴露于辐射的个体中的GI综合征的方法。

公开(公告)号：US20250032319A1

公开(公告)日：2025-01-30

申请号：US18915762

申请日：2024-10-15

Applicant: Thomas Jefferson University

Inventor： Elizabeth Rose Schoenberg ,  Stefani Lynne Samuels ,  Vivek Koratkar Bilolikar ,  Jennifer Lauren Doto ,  Matthew James Sharayko ,  Matthew Scott Keller ,  Mark Andrew Sunderland

IPC: A61F9/04 ,  A41D31/12 ,  A42B1/04 ,  A61K9/00 ,  B32B5/02 ,  B32B27/12

Abstract: An apparel system for applying topical treatments includes an article of apparel configured to cover and interface with a skin surface of a human body, the article of apparel including an oleophobic and moisture wicking layer. A method for applying a topical treatment is also disclosed.

公开(公告)号：US20250011698A1

公开(公告)日：2025-01-09

申请号：US18701966

申请日：2022-10-18

Applicant: Thomas Jefferson University

Inventor： Sangwon Kim

IPC: C12H1/056

Abstract: The present disclosure relates, in part, to compositions and methods for the at least partial removal of histamine from a fermented liquid. In one aspect, composition of the present disclosure comprises a histamine binding domain conjugated to a solid support via a cross-linker. In certain embodiments, the histamine binding domain comprises an aptamer. In certain embodiments, the histamine binding domain comprises an anti-histamine antibody.

公开(公告)号：US20240335184A1

公开(公告)日：2024-10-10

申请号：US18745131

申请日：2024-06-17

Applicant: Thomas Jefferson University

Inventor： Lydia C. Liao ,  Yan Yu

IPC: A61B8/08 ,  A61B6/00 ,  A61B6/50

CPC classification number: A61B8/5261 ,  A61B6/4417 ,  A61B6/502 ,  A61B6/5247 ,  A61B8/0825 ,  A61B8/483

Abstract: A system for breast cancer detection using co-localized ultrasound-mammography is disclosed. The system includes an examination box having a cavity connected to a side opening. A compression plate is connected to an actuator, the actuator configured to advance a surface of the compression plate towards a breast positioned within the cavity from the side opening to compress and stabilize the breast. An x-ray device is configured to generate at least one mammography image. An ultrasound probe is configured to generate at least one ultrasound image. A controller is operably connected to the x-ray device and ultrasound probe, the controller configured generate an image based on co-localization of the at least one mammography image and at the least one ultrasound image. A method of performing breast cancer detection and methods of breast imaging are also disclosed.

公开(公告)号：US12090323B2

公开(公告)日：2024-09-17

申请号：US17358851

申请日：2021-06-25

Applicant: The Trustees of the University of Pennsylvania ,  Thomas Jefferson University

Inventor： Daniel Kacy Cullen ,  James P. Harris ,  John A. Wolf ,  Han-Chiao Isaac Chen ,  Douglas H. Smith ,  Mijail Serruya

IPC: A61N1/36 ,  A61B5/00 ,  A61B5/24 ,  A61B5/291 ,  A61N1/05 ,  A61N5/06 ,  A61B5/01

CPC classification number: A61N1/36067 ,  A61B5/24 ,  A61B5/291 ,  A61B5/6868 ,  A61N1/05 ,  A61N1/0536 ,  A61N1/36182 ,  A61N5/0601 ,  A61N5/0622 ,  A61B5/0059 ,  A61B5/01 ,  A61B5/4082 ,  A61B5/4088 ,  A61B5/4094 ,  A61N1/0531

Abstract: In one aspect, the invention comprises an implantable living electrode comprising a substantially cylindrical extracellular matrix core; one or more neurons implanted along or within the substantially cylindrical extracellular matrix core, the one or more neurons including one or more optogenetic or magnetogenetic neurons proximal to a first end of the implantable living electrode.

公开(公告)号：US12090203B2

公开(公告)日：2024-09-17

申请号：US17595709

申请日：2020-05-29

Applicant: Drexel University ,  Thomas Jefferson University

Inventor： Margaret A. Wheatley ,  John Robert Eisenbrey ,  Brian E. Oeffinger ,  Purva Vaidya

IPC: A61K41/00 ,  A61K9/107 ,  A61K31/416 ,  A61K47/14 ,  A61K47/18 ,  A61K47/22 ,  A61K49/00

CPC classification number: A61K41/0033 ,  A61K9/1075 ,  A61K31/416 ,  A61K47/14 ,  A61K47/186 ,  A61K47/22 ,  A61K49/0082

Abstract: The present invention provides methods for preparing acoustically-sensitive microbubbles. The method includes the steps of: i) preparing a first surfactant solution comprising a first micelle-forming surfactant at a concentration above the critical micelle concentration (CMC); ii) adding one or more pharmaceutical compounds in a solvent to the first surfactant solution, thereby loading the micelles with the one or more pharmaceutical compounds; iii) preparing a second surfactant solution comprising a second surfactant, wherein the second surfactant comprises one or more matrix forming surfactants; iv) adding heat to the second surfactant solution to melt the surfactant and allowing the mixture to cool under rapid stirring; v) combining the second surfactant solution with the loaded micelles; vi) purging the surfactant mixture with a purging gas; vii) agitating the purged mixture under a constant stream of the purging gas; and, viii) separating the formed microbubbles by size.

公开(公告)号：US12083125B2

公开(公告)日：2024-09-10

申请号：US17859082

申请日：2022-07-07

Applicant: Thomas Jefferson University

Inventor： Janice L. Walker ,  Alexander Mazo ,  Svetlana Petruk ,  A. Sue Menko

IPC: A61K31/55 ,  A61K9/00

CPC classification number: A61K31/55 ,  A61K9/0014 ,  A61K9/0048 ,  A61K9/0051

Abstract: A therapeutic treatment for preventing or reducing the formation of fibrosis comprising administering to a patient a UTX or JMJD3 inhibitor that are effective in preventing or reducing fibrosis in situations wherein access to an injury or dysmorphogenetic tissues before the fibrotic process becomes established in the tissues.

公开(公告)号：US20240210401A1

公开(公告)日：2024-06-27

申请号：US18427042

申请日：2024-01-30

Applicant: Thomas Jefferson University

Inventor： Mathew L. THAKUR ,  Leonard G. GOMELLA

IPC: G01N33/574 ,  G01N33/58

CPC classification number: G01N33/574 ,  G01N33/582

Abstract: This invention relates to a method for detecting shed or circulating tumor cells in a biological fluid using labeled pituitary adenylate cyclase activating peptide or vasoactive intestinal peptide.

公开(公告)号：US12011446B2

公开(公告)日：2024-06-18

申请号：US17049235

申请日：2019-04-18

Applicant: Thomas Jefferson University

Inventor： Joel Rosenbloom ,  Edward John Macarak

IPC: A61K31/519 ,  A61P17/16

CPC classification number: A61K31/519 ,  A61P17/16

Abstract: A method of reducing the severity of radiation induced fibrosis (RIF) by administering to a patient at least a first dose of an MeK inhibitor such as trametinib between 0.01 mg to 2.0 mg, and after said radiation procedure, administering to said patient a further dose of the MeK inhibitor between 0.01 mg and 2.0 mg after the radiation procedure.