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1.发明申请ANGLED CRANIOTOME AND MINIMAL PLATING SYSTEM FOR IMPROVED COSMESIS AND STRUCTURAL INTEGRITY OF CRANIOTOMIES 有权ANGED CRANIOTOME AND MINIMAL PLATING SYSTEM FOR IMPROVED COSMESIS AND STRUCTURAL INTEGRITY OF CRANIOTOMIES公开(公告)号：US20160192948A1
公开(公告)日：2016-07-07
申请号：US14917135
申请日：2014-09-06
发明人： Chengyuan WU , Ashwini D. SHARAN
CPC分类号： A61B17/1695 , A61B17/1622 , A61B17/688
摘要： In accordance with one embodiment, a device for performing an angled craniotome includes an elongate handle, a footplate, a stem, and an elongate cutting bit. The elongate handle extends in a vertical direction. The footplate is spaced apart from the elongate handle and defines a plane generally perpendicular to the vertical direction. The footplate is offset from the handle in a horizontal direction where the horizontal direction is perpendicular to the vertical direction. The stem has a proximal end and a distal end. The proximal end is coupled to the handle and the distal end is coupled to the footplate. The stem extends from the handle at an oblique angle in the horizontal direction relative to the handle. The elongate cutting bit is coupled to the handle and extends from the handle toward the footplate at the oblique angle in the horizontal direction relative to the handle.
摘要翻译： 根据一个实施例，用于执行倾斜开颅器的装置包括细长手柄，脚踏板，杆和细长切割钻头。 细长手柄在垂直方向上延伸。 脚板与细长手柄间隔开，并且限定了一个垂直于垂直方向的平面。 脚板在水平方向垂直于垂直方向的水平方向上从手柄偏移。 茎具有近端和远端。 近端联接到手柄，并且远端联接到脚踏板。 杆从手柄以相对于把手的水平方向倾斜的角度延伸。 细长切割钻头联接到手柄并且在手柄朝向底板的相对于手柄的水平方向上以倾斜角度延伸。
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公开(公告)号：US20140255518A1
公开(公告)日：2014-09-11
申请号：US14114727
申请日：2012-04-27
申请人： Peng Li , Scott A. Waldman , Evan Wuthrick
发明人： Peng Li , Scott A. Waldman , Evan Wuthrick
IPC分类号： C07K14/58 , C07K14/575 , A61K45/06 , A61K38/22
CPC分类号： C07K14/58 , A61K38/10 , A61K38/16 , A61K38/22 , A61K38/2242 , A61K45/06 , C07K14/575
摘要： Compositions comprising a guanylyl cyclase C agonist in an amount effective to protect intestinal tissue against radiation or chemotherapy and methods of using such compositions to prevent GI syndrome in cancer patient undergoing radiation or chemotherapy and in individuals exposed to or susceptible to exposure to radiation are disclosed.
摘要翻译： 公开了包含有效保护肠组织免受辐射或化学疗法的量的鸟苷酸环化酶C激动剂的组合物和使用这些组合物来预防接受放射或化疗的癌症患者中的GI综合征以及暴露于或易于暴露于辐射的个体中的GI综合征的方法。
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3.发明公开公开(公告)号：US20240335184A1
公开(公告)日：2024-10-10
申请号：US18745131
申请日：2024-06-17
发明人： Lydia C. Liao , Yan Yu
CPC分类号： A61B8/5261 , A61B6/4417 , A61B6/502 , A61B6/5247 , A61B8/0825 , A61B8/483
摘要： A system for breast cancer detection using co-localized ultrasound-mammography is disclosed. The system includes an examination box having a cavity connected to a side opening. A compression plate is connected to an actuator, the actuator configured to advance a surface of the compression plate towards a breast positioned within the cavity from the side opening to compress and stabilize the breast. An x-ray device is configured to generate at least one mammography image. An ultrasound probe is configured to generate at least one ultrasound image. A controller is operably connected to the x-ray device and ultrasound probe, the controller configured generate an image based on co-localization of the at least one mammography image and at the least one ultrasound image. A method of performing breast cancer detection and methods of breast imaging are also disclosed.
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公开(公告)号：US12090323B2
公开(公告)日：2024-09-17
申请号：US17358851
申请日：2021-06-25
发明人： Daniel Kacy Cullen , James P. Harris , John A. Wolf , Han-Chiao Isaac Chen , Douglas H. Smith , Mijail Serruya
CPC分类号： A61N1/36067 , A61B5/24 , A61B5/291 , A61B5/6868 , A61N1/05 , A61N1/0536 , A61N1/36182 , A61N5/0601 , A61N5/0622 , A61B5/0059 , A61B5/01 , A61B5/4082 , A61B5/4088 , A61B5/4094 , A61N1/0531
摘要： In one aspect, the invention comprises an implantable living electrode comprising a substantially cylindrical extracellular matrix core; one or more neurons implanted along or within the substantially cylindrical extracellular matrix core, the one or more neurons including one or more optogenetic or magnetogenetic neurons proximal to a first end of the implantable living electrode.
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公开(公告)号：US12090203B2
公开(公告)日：2024-09-17
申请号：US17595709
申请日：2020-05-29
CPC分类号： A61K41/0033 , A61K9/1075 , A61K31/416 , A61K47/14 , A61K47/186 , A61K47/22 , A61K49/0082
摘要： The present invention provides methods for preparing acoustically-sensitive microbubbles. The method includes the steps of: i) preparing a first surfactant solution comprising a first micelle-forming surfactant at a concentration above the critical micelle concentration (CMC); ii) adding one or more pharmaceutical compounds in a solvent to the first surfactant solution, thereby loading the micelles with the one or more pharmaceutical compounds; iii) preparing a second surfactant solution comprising a second surfactant, wherein the second surfactant comprises one or more matrix forming surfactants; iv) adding heat to the second surfactant solution to melt the surfactant and allowing the mixture to cool under rapid stirring; v) combining the second surfactant solution with the loaded micelles; vi) purging the surfactant mixture with a purging gas; vii) agitating the purged mixture under a constant stream of the purging gas; and, viii) separating the formed microbubbles by size.
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公开(公告)号：US12083125B2
公开(公告)日：2024-09-10
申请号：US17859082
申请日：2022-07-07
CPC分类号： A61K31/55 , A61K9/0014 , A61K9/0048 , A61K9/0051
摘要： A therapeutic treatment for preventing or reducing the formation of fibrosis comprising administering to a patient a UTX or JMJD3 inhibitor that are effective in preventing or reducing fibrosis in situations wherein access to an injury or dysmorphogenetic tissues before the fibrotic process becomes established in the tissues.
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7.发明公开公开(公告)号：US20240210401A1
公开(公告)日：2024-06-27
申请号：US18427042
申请日：2024-01-30
IPC分类号： G01N33/574 , G01N33/58
CPC分类号： G01N33/574 , G01N33/582
摘要： This invention relates to a method for detecting shed or circulating tumor cells in a biological fluid using labeled pituitary adenylate cyclase activating peptide or vasoactive intestinal peptide.
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公开(公告)号：US12011446B2
公开(公告)日：2024-06-18
申请号：US17049235
申请日：2019-04-18
IPC分类号： A61K31/519 , A61P17/16
CPC分类号： A61K31/519 , A61P17/16
摘要： A method of reducing the severity of radiation induced fibrosis (RIF) by administering to a patient at least a first dose of an MeK inhibitor such as trametinib between 0.01 mg to 2.0 mg, and after said radiation procedure, administering to said patient a further dose of the MeK inhibitor between 0.01 mg and 2.0 mg after the radiation procedure.
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公开(公告)号：US11998550B2
公开(公告)日：2024-06-04
申请号：US16607032
申请日：2018-04-20
IPC分类号： A61K31/519 , A61K9/12 , A61P11/00 , A61P41/00
CPC分类号： A61K31/519 , A61K9/12 , A61P11/00 , A61P41/00
摘要： A method of reducing the severity of abdominal adhesion due to surgical complications comprising: administering to said patient at least a first dose of trametinib between 0.01 mg to 2.0 mg, and after said surgical procedure, administering to said patient a further dose of trametinib between 0.01 mg to 2.0 mg, daily, for at least seven days post-surgery.
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公开(公告)号：US20240090817A1
公开(公告)日：2024-03-21
申请号：US18510470
申请日：2023-11-15
CPC分类号： A61B5/374 , A61B5/384 , A61N1/36025 , A61N1/36171
摘要： A device and a signal processing method that can monitor human memory performance by recognizing and characterizing high-gamma (65-250 Hz) and beta (14-30 Hz) band oscillations in the left Brodmann Area 40 (BA40) of the brain that correspond with the strength of memory encoding or correct recall. The signal processing method detects high-gamma and beta band oscillations in the electrical signals recorded from left BA40, and quantifies the spectral content, power, duration, onset, and offset of the oscillations. The oscillation's properties are used to classify the subject's memory performance on the basis of a comparison with the subject's prior human memory performance and the properties of the corresponding oscillations. A report of the subject's current memory performance can be utilized in a closed loop brain stimulation device that serves the purpose of enhancing human memory performance.
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