- 专利标题： Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use
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申请号： US10992146申请日： 2004-11-18
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公开(公告)号： US07141587B2公开(公告)日： 2006-11-28
- 发明人: Robert Steven Kania , Steven Lee Bender , Allen J. Borchardt , Stephan James Cripps , Ye Hua , Michael David Johnson , Theodore Otto Johnson, Jr. , Hiep The Luu , Cynthia Louise Palmer , Siegfried Heinz Reich , Anna Maria Tempczyk-Russell , Min Teng , Christine Thomas , Michael David Varney , Michael Brennan Wallace , Michael Raymond Collins
- 申请人： Robert Steven Kania , Steven Lee Bender , Allen J. Borchardt , Stephan James Cripps , Ye Hua , Michael David Johnson , Theodore Otto Johnson, Jr. , Hiep The Luu , Cynthia Louise Palmer , Siegfried Heinz Reich , Anna Maria Tempczyk-Russell , Min Teng , Christine Thomas , Michael David Varney , Michael Brennan Wallace , Michael Raymond Collins
- 申请人地址： US CA La Jolla
- 专利权人： Agouron Pharmaceuticals, Inc.
- 当前专利权人： Agouron Pharmaceuticals, Inc.
- 当前专利权人地址： US CA La Jolla
- 代理商 Edward D. Robinson; Bryan C. Zielinski
- 主分类号： C07D401/02
- IPC分类号： C07D401/02 ; A61K31/44
摘要：
Indazole compounds that modulate and/or inhibit the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction and thereby modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer and other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.
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