摘要:
Indazole compounds that modulate and/or inhibit the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction and thereby modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer and other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.
摘要:
Indazole compounds that modulate and/or inhibit the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction and thereby modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer and other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.
摘要:
Indazole compounds that modulate and/or inhibit the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction and thereby modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer and other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.
摘要:
Indazole compounds that modulate and/or inhibit the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction and thereby modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer and other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.
摘要:
Novel non-peptide GLP-1 agonists, pharmaceutical compositions comprising them, use of the non-peptide GLP-1 agonists for the preparation of pharmaceutical compositions and methods for the treatment and/or prevention of disorders and diseases wherein an activation of the human GLP-1 receptor is beneficial, especially metabolic disorders such as IGT, Type 1 diabetes, Type 2 diabetes and obesity.
摘要:
A movie game method and apparatus is provided including a score pad having a plurality of sheets of paper and a timer. Also included is a stack of a plurality of playing cards each having a top face, a bottom face, and a periphery formed therebetween. Each of the playing cards of the stack includes a top face with an actor thereon and a bottom face with a list of movies thereon in which the actor appeared.
摘要:
A compound or pharmaceutically acceptable salts thereof of Formula (I) wherein the substituents are as defined herein, which are useful as kinase inhibitors.
摘要:
A tactile kinesthetic assistant is a device that allows a person to use the senses of sight, touch and hearing to gather information. Tactile kinesthetic assistants can be used, for example, to help a person retrieve information related to a specific word or phrase (e.g., a student learning to read), to allow a person to determine the status of a person or thing (e.g., a nurse retrieving medical records), to allow a person to obtain current information (e.g., a stock broker retrieving stock prices). In one embodiment, a tactile kinesthetic assistant includes a thimble and an ear piece. The thimble includes a scanner that allows the user to scan one or more words. The representations of the one or more words are used to retrieve information via a network and the retrieved information is provided to the user through an ear piece.
摘要:
A method for localising a target 2 (fi. a tumour) in an object 4 (fi. human tissue) by means of scanning the object with a fan shaped X-ray beam 6. In known methods the X-ray beam is scanned twice over the object. In the first scan a shadow image of the object 4 and the target 2 in it is projected on an X-ray detector 10. In the second scan the position and the orientation of the X-ray beam 6 differs from the position and orientation of it in the first scan. Also during the second scan a shadow image of the object and the target is projected on the X-ray detector, in such a way that the positions of the target on the detector are mutually different. In this way the height of the target above the detector surface 10 may be calculated from the distance between the two shadow images of the target if both positions of the X-ray beam as well as both orientations are known. According to the invention it is proposed to translate and simultaneously rotate the X-ray beam 6 during the scan, the translatory and rotational movements being connected in such a way that the shadow image 12 of the target 2 is kept on the surface 10 of the detector during the scan. In this way it is possible to measure the translation d of that image during the scan, from which translation in combination with the translation D and the rotation during the scan the height of the target 2 above the detector surface 10 may be calculated. In this way only one scan is needed.