- 专利标题： Nucleic acid injected into hapatic vein lumen and delivered to primate liver
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申请号： US10310398申请日： 2002-12-05
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公开(公告)号： US07144869B2公开(公告)日： 2006-12-05
- 发明人: Jon A. Wolff , Julia Hegge , James E. Hagstrom , Vladimir G. Budker
- 申请人： Jon A. Wolff , Julia Hegge , James E. Hagstrom , Vladimir G. Budker
- 申请人地址： US WI Madison
- 专利权人： Mirus Bio Corporation
- 当前专利权人： Mirus Bio Corporation
- 当前专利权人地址： US WI Madison
- 代理商 Mark K. Johnson; Kirk Evans
- 主分类号： A61K31/70
- IPC分类号： A61K31/70 ; C12N15/74
摘要：
Processes are described for obtaining high levels of gene expression in primates after injection of nucleic acid to the liver via the lumen of the hepatic vein. The described process results in high level of gene expression with transient increases in liver enzymes.