- 专利标题： Cyclic phosphate diesters of 1,3-propane-1-aryl diols and their use in preparing prodrugs
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申请号： US10698924申请日： 2003-10-31
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公开(公告)号： US07148349B2公开(公告)日： 2006-12-12
- 发明人: K. Raja Reddy , William Craigo , Zhili Sun , Serge Boyer , Bheemarao G. Ugarkar
- 申请人： K. Raja Reddy , William Craigo , Zhili Sun , Serge Boyer , Bheemarao G. Ugarkar
- 申请人地址： US CA La Jolla
- 专利权人： Metabasis Therapeutics, Inc.
- 当前专利权人： Metabasis Therapeutics, Inc.
- 当前专利权人地址： US CA La Jolla
- 代理机构： Sterne, Kessler, Goldstein & Fox P.L.L.C.
- 主分类号： C07D239/02
- IPC分类号： C07D239/02 ; C07D487/06 ; C07C9/02
摘要：
Compounds of Formula I, their preparation and synthetic intermediates, and their use in the synthesis of prodrugs: wherein: V and L are trans relative to one another; V is selected from group consisting of carbocyclic aryl, substituted carbocyclic aryl, heteroaryl, and substituted heteroaryl; and L is a leaving group selected from the group consisting of halogen, alkyl sulfonate, aryloxy optionally substituted with 1–2 substituents, N-containing heteroaryl, and N-hydroxy-nitrogen containing heteroaryl; and salts thereof.