发明授权
US07160886B2 Acylated piperazine derivatives as melanocortin-4 receptor agonists
失效
酰基化哌嗪衍生物作为黑皮质素-4受体激动剂
- 专利标题： Acylated piperazine derivatives as melanocortin-4 receptor agonists
- 专利标题（中）： 酰基化哌嗪衍生物作为黑皮质素-4受体激动剂
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申请号： US10788859申请日： 2004-02-27
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公开(公告)号： US07160886B2公开(公告)日： 2007-01-09
- 发明人: Raman K. Bakshi , Liangqin Guo , Qingmei Hong , Ravi P. Nargund , Patrick G. Pollard , Iyassu K. Sebhat , Feroze Ujjainwalla , Zhixiong Ye
- 申请人： Raman K. Bakshi , Liangqin Guo , Qingmei Hong , Ravi P. Nargund , Patrick G. Pollard , Iyassu K. Sebhat , Feroze Ujjainwalla , Zhixiong Ye
- 申请人地址： US NJ Rahway
- 专利权人： Merck & Co., Inc.
- 当前专利权人： Merck & Co., Inc.
- 当前专利权人地址： US NJ Rahway
- 代理商 Baerbel R. Brown; Melvin Winokur
- 主分类号： A61K31/497
- IPC分类号： A61K31/497 ; C07D401/12 ; C07D403/12 ; C07D413/12 ; C07D417/12
摘要：
Certain novel N-acylated piperazine derivatives are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the activation of MC-4R, such as obesity, diabetes, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.