发明授权
- 专利标题： Amino nicotinate derivatives as glucokinase (GLK) modulators
- 专利标题（中）： 氨基烟酸衍生物作为葡萄糖激酶（GLK）调节剂
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申请号： US10482572申请日： 2002-06-24
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公开(公告)号： US07160906B2公开(公告)日： 2007-01-09
- 发明人: Barry Raymond Hayter , Gordon Stuart Currie , Rodney Brian Hargreaves , Roger James , Clifford David Jones , Darren McKerrecher , Joanne Victoria Allen , Peter William Rodney Caulkett , Craig Johnstone , Harold Gaskin
- 申请人： Barry Raymond Hayter , Gordon Stuart Currie , Rodney Brian Hargreaves , Roger James , Clifford David Jones , Darren McKerrecher , Joanne Victoria Allen , Peter William Rodney Caulkett , Craig Johnstone , Harold Gaskin
- 申请人地址： SE Sodertalje
- 专利权人： AstraZeneca AB
- 当前专利权人： AstraZeneca AB
- 当前专利权人地址： SE Sodertalje
- 代理机构： Morgan, Lewis & Bockius LLP
- 优先权： SE0102300 20010626
- 国际申请： PCT/GB02/02873 WO 20020624
- 国际公布： WO03/000267 WO 20030103
- 主分类号： A61K31/44
- IPC分类号： A61K31/44 ; C07D213/75
摘要：
The invention related to novel compounds of Formula (I) or a salt, solvate or prodrug thereof, wherein R1, R2, R3, n and m are as described in the specification, useful in the treatment of a disease or condition mediated through glucokinase (GLK), such as type 2 diabetes. The invention also relates to methods for preparing compounds of Formula (I) and their use as medicaments in the treatment of diseases mediated by glucokinase.