公开(公告)号：US07160906B2

公开(公告)日：2007-01-09

申请号：US10482572

申请日：2002-06-24

申请人： Barry Raymond Hayter ,  Gordon Stuart Currie ,  Rodney Brian Hargreaves ,  Roger James ,  Clifford David Jones ,  Darren McKerrecher ,  Joanne Victoria Allen ,  Peter William Rodney Caulkett ,  Craig Johnstone ,  Harold Gaskin

发明人： Barry Raymond Hayter ,  Gordon Stuart Currie ,  Rodney Brian Hargreaves ,  Roger James ,  Clifford David Jones ,  Darren McKerrecher ,  Joanne Victoria Allen ,  Peter William Rodney Caulkett ,  Craig Johnstone ,  Harold Gaskin

IPC分类号： A61K31/44 ,  C07D213/75

CPC分类号： C07D213/80 ,  A61K31/443 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5377 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14

摘要： The invention related to novel compounds of Formula (I) or a salt, solvate or prodrug thereof, wherein R1, R2, R3, n and m are as described in the specification, useful in the treatment of a disease or condition mediated through glucokinase (GLK), such as type 2 diabetes. The invention also relates to methods for preparing compounds of Formula (I) and their use as medicaments in the treatment of diseases mediated by glucokinase.

摘要翻译： 本发明涉及新型式（I）化合物或其盐，溶剂合物或前药，其中R 1，R 2，R 3， ，n和m如说明书中所述，可用于治疗通过葡萄糖激酶（GLK）介导的疾病或病症，例如2型糖尿病。 本发明还涉及制备式（I）化合物及其作为药物用于治疗由葡萄糖激酶介导的疾病的用途的方法。

公开(公告)号：US07199140B2

公开(公告)日：2007-04-03

申请号：US10482264

申请日：2002-06-24

申请人： Barry Raymond Hayter ,  Gordon Stuart Currie ,  Rodney Brian Hargreaves ,  Peter William Rodney Caulkett ,  Roger James

发明人： Barry Raymond Hayter ,  Gordon Stuart Currie ,  Rodney Brian Hargreaves ,  Peter William Rodney Caulkett ,  Roger James

IPC分类号： A61K31/445 ,  C07D213/50

CPC分类号： C07D213/78 ,  C07D213/80 ,  C07D213/82 ,  C07D239/28 ,  C07D277/56 ,  C07D307/68 ,  C07D405/12 ,  C07D413/04 ,  C07D413/12 ,  C07D417/12

摘要： The invention relates to novel compounds of Formula (I) or a salt, solvate or prodrug thereof, wherein A, R1, R2, R3, n and m are described in the specification, useful in the treatment of a disease or condition mediated through glucokinase (GLK), such as type 2 diabetes. The invention also relates to methods for preparing compounds of Formula (I) and their use as medicaments in the treatment of diseases mediated by glucokinase.

摘要翻译： 本发明涉及新的式（I）化合物或其盐，溶剂合物或前药，其中A，R 1，R 2，R 3， SUP>，n和m在说明书中描述，可用于治疗

公开(公告)号：US07427616B2

公开(公告)日：2008-09-23

申请号：US10523401

申请日：2003-08-01

申请人： Richard William Arthur Luke ,  Clifford David Jones ,  William McCoull ,  Barry Raymond Hayter

发明人： Richard William Arthur Luke ,  Clifford David Jones ,  William McCoull ,  Barry Raymond Hayter

IPC分类号： C07D473/34 ,  C07D513/04 ,  C07D498/04 ,  C07D495/04 ,  C07D491/04 ,  C07D487/04 ,  A61K31/519

CPC分类号： C07D487/04 ,  C07D473/34 ,  C07D491/04 ,  C07D495/04 ,  C07D513/04

摘要： A compound of the Formula (I), wherein A together with the carbon atoms to which it is attached forms a fused 5-membered heteroaryl ring, wherein said heteroaryl ring contains 1 or 2 heteroatoms selected from O, N and S, and wherein the 5-membered ring containing G is linked to the ring formed by A in the meta position to the bridgehead carbon marked # in Formula (I): G is selected from O, S and NR5; Z is selected from N and CR6; Q1 is selected from optionally substituted aryl and heteroaryl, and the substituents R1 to R6 are as defined in the text for use in the production of an anti-angiogenic effect in a warm blooded animal such as man.

摘要翻译： 式（I）的化合物，其中A与连接的碳原子一起形成稠合的5元杂芳基环，其中所述杂芳基环含有1或2个选自O，N和S的杂原子，并且其中 含有G的5元环与在间位A中形成的环连接在通式（I）中标记为＃的桥头碳上：G选自O，S和NR 5; Z选自N和CR 6; Q 1选自任选取代的芳基和杂芳基，并且取代基R 1至R 6如文中所定义，用于 在温血动物如人中产生抗血管生成作用。