Invention Grant
US07160914B2 Compounds that exhibit specific molecular recognition of mixed nucleic acid sequences and bind in the DNA minor groove as a dimer
失效
显示混合核酸序列的特异性分子识别并在DNA小沟中作为二聚体结合的化合物
- Patent Title: Compounds that exhibit specific molecular recognition of mixed nucleic acid sequences and bind in the DNA minor groove as a dimer
- Patent Title (中): 显示混合核酸序列的特异性分子识别并在DNA小沟中作为二聚体结合的化合物
-
Application No.: US11035627Application Date: 2005-01-14
-
Publication No.: US07160914B2Publication Date: 2007-01-09
- Inventor: W. David Wilson , David W. Boykin , Richard R. Tidwell
- Applicant: W. David Wilson , David W. Boykin , Richard R. Tidwell
- Applicant Address: US NC Chapel Hill US GA Atlanta
- Assignee: The University of North Carolina at Chapel Hill,Georgia State University Research Foundation, Inc.
- Current Assignee: The University of North Carolina at Chapel Hill,Georgia State University Research Foundation, Inc.
- Current Assignee Address: US NC Chapel Hill US GA Atlanta
- Agency: Jenkins, Wilson, Taylor, & Hunt, P.A.
- Main IPC: A61K31/4184
- IPC: A61K31/4184 ; A61K31/4164 ; C07D403/04 ; C12Q1/04 ; C12Q1/24
Abstract:
Asymmetric derivatives of furamidines with one of the phenyl rings of furamidine replaced with a benzimidazole have been found by quantitative footprinting analyses to bind GC containing sites on DNA more strongly than to pure AT sequences. These compounds have been shown to bind in the minor groove at specific GC containing sequences of DNA in a highly cooperative manner as a stacked dimer. Compounds of the present invention find use in selectively binding mixed sequence DNA, and may also be used in methods of regulating gene expression, methods of treating opportunistic infections and cancer, as well as in methods of detecting certain sequences of DNA.
Public/Granted literature
Information query
IPC分类:
