Invention Grant
US07166614B2 Tetrahydropyranyl cyclopentyl tetrahydroisoquinoline modulators of chemokine receptor activity
失效
趋化因子受体活性的四氢吡喃基环戊基四氢异喹啉调节剂
- Patent Title: Tetrahydropyranyl cyclopentyl tetrahydroisoquinoline modulators of chemokine receptor activity
- Patent Title (中): 趋化因子受体活性的四氢吡喃基环戊基四氢异喹啉调节剂
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Application No.: US10512925Application Date: 2003-04-25
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Publication No.: US07166614B2Publication Date: 2007-01-23
- Inventor: Richard Jiao , Stephen D. Goble , Sander G. Mills , Gregori Morriello , Alexander Pasternak , Lihu Yang , Changyou Zhou , Gabor Butora , Shankaran Kothandaraman , Deodialsingh Guiadeen , Christopher Moyes
- Applicant: Richard Jiao , Stephen D. Goble , Sander G. Mills , Gregori Morriello , Alexander Pasternak , Lihu Yang , Changyou Zhou , Gabor Butora , Shankaran Kothandaraman , Deodialsingh Guiadeen , Christopher Moyes
- Applicant Address: US NJ Rahway GB Hertfordshire
- Assignee: Merck & Co., Inc.,Merck Sharp & Dohme Limited
- Current Assignee: Merck & Co., Inc.,Merck Sharp & Dohme Limited
- Current Assignee Address: US NJ Rahway GB Hertfordshire
- Agent David A. Rubin; David L. Rose
- International Application: PCT/US03/13121 WO 20030425
- International Announcement: WO03/093231 WO 20031113
- Main IPC: C07D217/02
- IPC: C07D217/02 ; A61K31/47
Abstract:
The present invention is directed to compounds of the formula I: I(wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, n and the dashed line are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptor CCR-2
Public/Granted literature
- US20060089379A1 Tetrahydropyranyl cyclopentyl tetrahydroisoquinoline modulators of chemokine receptor activity Public/Granted day:2006-04-27
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