发明授权
- 专利标题： Multifunctional monoclonal antibodies directed to peptidoglycan of gram-positive bacteria
- 专利标题（中）： 针对革兰氏阳性菌的肽聚糖的多功能单克隆抗体
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申请号： US10323903申请日： 2002-12-20
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公开(公告)号： US07169903B2公开(公告)日： 2007-01-30
- 发明人: Richard F. Schuman , John Fitzgerald Kokai-Kun , Simon J. Foster , Jeffrey R. Stinson , Gerald Walter Fischer
- 申请人： Richard F. Schuman , John Fitzgerald Kokai-Kun , Simon J. Foster , Jeffrey R. Stinson , Gerald Walter Fischer
- 申请人地址： US MD Gaithersburg
- 专利权人： Biosynexus Incorporated
- 当前专利权人： Biosynexus Incorporated
- 当前专利权人地址： US MD Gaithersburg
- 代理机构： Lahive & Cockfield, LLP
- 代理商 Amy E. Mandragouras, Esq.; Megan E. Williams, Esq.
- 主分类号： C12P21/08
- IPC分类号： C12P21/08 ; C07K16/00 ; A61K39/085 ; C07H21/04
摘要：
The present invention encompasses protective monoclonal antibodies that bind to peptidoglycan of Gram-positive bacteria. The antibodies also bind to whole bacteria and enhance phagocytosis and killing of the bacteria in vitro and block nasal colonization by Gram-positive bacteria in vivo. The invention also provides human, humanized and chimeric antibodies. The invention also sets forth the heavy chain and light chain variable regions of an antibody within the invention.
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