发明授权
- 专利标题： Nucleic acid formulations for gene delivery and methods of use
- 专利标题（中）： 用于基因递送的核酸制剂和使用方法
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申请号： US10234406申请日： 2002-09-03
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公开(公告)号： US07173116B2公开(公告)日： 2007-02-06
- 发明人: Jason Fewell , Fiona MacLaughlin , Louis C. Smith , Francois Nicol , Alain Rolland
- 申请人： Jason Fewell , Fiona MacLaughlin , Louis C. Smith , Francois Nicol , Alain Rolland
- 申请人地址： US CA San Diego
- 专利权人： Genetronics Biomedical Corporation
- 当前专利权人： Genetronics Biomedical Corporation
- 当前专利权人地址： US CA San Diego
- 代理机构： Wong, Cabello, Lutsch, Rutherford & Brucculeri, LLP
- 主分类号： C07H21/02
- IPC分类号： C07H21/02 ; A61K38/00 ; C07K1/00 ; C12N15/00
摘要：
A nucleic acid formulation for use in gene delivery comprising a nucleic acid and an anionic polymer is disclosed. Examples of the anionic polymer includes aniionic amino acid polymer or poly-amino acid (such as poly-L-glutamic acid, poly-D-glutamic acid, poly-L-aspartic acid, poly-D-aspartic acid), poly-acrylic acid, polynucleotides, poly galacturonic acid, and poly vinyl sulfate.
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