发明授权
- 专利标题： Selective RXR ligands
- 专利标题（中）： 选择性RXR配体
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申请号： US10490805申请日： 2002-09-16
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公开(公告)号： US07173134B2公开(公告)日： 2007-02-06
- 发明人: Curt Dale Haffner , Istvan Kaldor , Darryl Lynn McDougald , Aaron Bayne Miller
- 申请人： Curt Dale Haffner , Istvan Kaldor , Darryl Lynn McDougald , Aaron Bayne Miller
- 申请人地址： US PA Philadelphia
- 专利权人： SmithKline Beecham Corporation
- 当前专利权人： SmithKline Beecham Corporation
- 当前专利权人地址： US PA Philadelphia
- 代理商 Amy H. Fix
- 国际申请： PCT/US02/29298 WO 20020916
- 国际公布： WO03/027090 WO 20030403
- 主分类号： C07D491/048
- IPC分类号： C07D491/048 ; C07D263/56 ; C07D307/80 ; C07D307/85 ; C07D333/56 ; C07D405/04 ; C07D411/04
摘要：
The present invention includes novel retinoid compounds that have selectivity as RXR agonists on one or more isoforms of RXR, currently, RXRα, RXRβ, or RXRγ. The present compounds, and pharmaceutical compositions incorporating these compounds, therefore, are effective in treating conditions mediated by RXRs. Among other physiological responses, the compounds of the present invention reduce blood glucose and maintain body weight, and, thus, are useful for the treatment of diabetes (NIDDIM) and obesity.
公开/授权文献
- US20040198980A1 Selective rxr ligands 公开/授权日：2004-10-07
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