发明授权
US07176295B2 Systematic evolution of ligands by exponential enrichment: blended SELEX
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配体通过指数富集系统演化：混合SELEX
- 专利标题： Systematic evolution of ligands by exponential enrichment: blended SELEX
- 专利标题（中）： 配体通过指数富集系统演化：混合SELEX
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申请号： US10263456申请日： 2002-10-02
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公开(公告)号： US07176295B2公开(公告)日： 2007-02-13
- 发明人: Gregory Biesecker , Sumeda Jayasena , Larry Gold , Drew Smith , Gary P. Kirschenheuter
- 申请人： Gregory Biesecker , Sumeda Jayasena , Larry Gold , Drew Smith , Gary P. Kirschenheuter
- 申请人地址： US CA Foster City
- 专利权人： Gilead Sciences, Inc.
- 当前专利权人： Gilead Sciences, Inc.
- 当前专利权人地址： US CA Foster City
- 代理机构： Swanson & Bratschun LLC
- 主分类号： C07H21/04
- IPC分类号： C07H21/04 ; C12Q1/68 ; C12P19/34 ; C07H21/02
摘要：
A method is described for generating blended nucleic acid ligands containing non-nucleic acid functional units. Specifically, a SELEX identified RNA ligand to the integrin gpIIbIIIa is conjugated to the peptide Gly-Arg-Gly-Asp-Thr-Pro (SEQ ID NO:1). This blended RNA ligand inhibits the biological activity of gpIIbIIIa with high specificity. Also described is a single-stranded DNA ligand to elastase coupled to N-methoxysuccinyl-Ala-Ala-Pro-Val-chloromethyl ketone (SEQ ID NO:2). This elastase blended nucleic acid ligand inhibits the biological activity of elastase.
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