发明授权
- 专利标题： Oncokinase fusion polypeptides associated with hyperproliferative and related disorders, nucleic acids encoding the same and methods for detecting and identifying the same
- 专利标题（中）： 与过度增殖和相关病症相关的肿瘤酶融合多肽，编码其的核酸以及用于检测和鉴定相同的方法
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申请号： US10637356申请日： 2003-08-08
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公开(公告)号： US07195876B2公开(公告)日： 2007-03-27
- 发明人: Roger Briesewitz , John H. Griffin
- 申请人： Roger Briesewitz , John H. Griffin
- 申请人地址： US CA South San Francisco
- 专利权人： Theravance, Inc.
- 当前专利权人： Theravance, Inc.
- 当前专利权人地址： US CA South San Francisco
- 代理商 Jeffrey A. Hagenah; Roberta P. Saxon
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; C12Q1/48 ; C12N9/12 ; C07H21/04
摘要：
Oncokinase fusion polypeptides associated with hyperproliferative disorders and the polynucleotides encoding for such fusion polypeptides are provided. The fusion polypeptides have a C-terminal tyrosine kinase domain fused to an N-terminal domain that is not normally fused to the C-terminal tyrosine kinase domain and they possess constitutively activated tyrosine kinase activity. Also provided are methods for detecting and identifying the fusion polypeptides and polynucleotides and methods of diagnosing disease conditions associated with the fusion polypeptides and polynucleotides. In addition, screening assays for identifying agents useful for treating disease conditions associated with such fusion polypeptides and polynucleotides are provided. Furthermore, methods of treating disease conditions associated with the presence of the fusion polypeptides are provided.
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