发明授权
US07198911B2 Identification and cloning of a novel human gene, RET16, involved in the intracellular signaling cascade
失效
鉴定和克隆参与细胞内信号传导级联的新型人基因RET16
- 专利标题： Identification and cloning of a novel human gene, RET16, involved in the intracellular signaling cascade
- 专利标题（中）： 鉴定和克隆参与细胞内信号传导级联的新型人基因RET16
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申请号： US10077111申请日： 2002-02-15
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公开(公告)号： US07198911B2公开(公告)日： 2007-04-03
- 发明人: C. Gordon Todderud , Joshua Finger , Jill Rillema
- 申请人： C. Gordon Todderud , Joshua Finger , Jill Rillema
- 申请人地址： US NJ Princeton
- 专利权人： Bristol-Myers Squibb Company
- 当前专利权人： Bristol-Myers Squibb Company
- 当前专利权人地址： US NJ Princeton
- 代理商 Nickki L. Parlet; Stephen C. D'Amico
- 主分类号： C12P12/06
- IPC分类号： C12P12/06 ; C12Q1/68 ; C12N15/63 ; C07H21/02 ; C07H21/04
摘要：
The present invention describes a newly discovered polynucleotide encoding a protein involved in the cell signaling cascade, called RET16, cloned, isolated and identified from TNF-alpha stimulated human microvascular endothelial cells, as well as mouse and rat RET16 orthologs thereof. Also described are the RET16 polypeptide sequence, expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies related to the polynucleotide and/or polypeptide of the present invention. Methods for screening for modulators, particularly inhibitors, of the human RET16 protein, and use of the RET16 polynucleotide and polypeptide for therapeutics and diagnostics are described.
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