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    Babesia canis vaccine
    2.
    发明授权
    Babesia canis vaccine 失效

    公开(公告)号：US07090849B2

    公开(公告)日：2006-08-15

    申请号：US10087573

    申请日：2002-02-28

    Applicant: Theodorus Petrus Maria Schetters ,  Bernard Pierre Dominique Carcy ,  Pascal Robert Drakulovski

    Inventor： Theodorus Petrus Maria Schetters ,  Bernard Pierre Dominique Carcy ,  Pascal Robert Drakulovski

    IPC: A61K39/018 ,  A61K39/00 ,  C12N15/09 ,  C12P12/06 ,  C07H21/04

    CPC classification number: C07K14/44 ,  A61K39/00

    Abstract: The present invention relates to nucleic acid sequences encoding novel Babesia canis associated proteins and to cDNA fragments, recombinant DNA molecules and live recombinant carriers comprising these sequences. Furthermore, the invention relates to host cells comprising such nucleic acid sequences, cDNA fragments, recombinant DNA molecules and live recombinant carriers. Also, the invention relates to proteins encoded by these nucleotide sequences, to vaccines for combating Babesia canis infections comprising these proteins or genetic material encoding these proteins and methods for the preparation of vaccines. Another embodiment of the invention relates to these Babesia canis associated proteins for use in vaccines and to the use of the Babesia canis associated proteins in the manufacture of vaccines. Finally the invention relates to diagnostic tools for the detection of Babesia canis associated nucleic acid sequences, for the detection of Babesia canis associated antigens and for the detection of antibodies against Babesia canis associated antigenic material.

    Polynucleotides related to murine anti-idiotype antibody 11D10 and methods of use thereof
    3.
    发明授权
    Polynucleotides related to murine anti-idiotype antibody 11D10 and methods of use thereof 失效
    与鼠抗独特型抗体11D10相关的多核苷酸及其使用方法

    公开(公告)号：US07083943B1

    公开(公告)日：2006-08-01

    申请号：US08836455

    申请日：1996-12-19

    Applicant: Malaya Chatterjee ,  Kenneth A. Foon ,  Sunil K. Chatterjee

    Inventor： Malaya Chatterjee ,  Kenneth A. Foon ,  Sunil K. Chatterjee

    IPC: C12P12/06

    CPC classification number: C07K16/3015 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/505 ,  C07K16/4266 ,  C07K2319/00 ,  C12N2799/023 ,  G01N33/57415 ,  G01N33/57492 ,  G01N33/686 ,  G01N2333/4725

    Abstract: The present invention provides a monoclonal and-idiotype antibody 11D10 that elicits an immune response against a specific epitope of a high molecular weight mucin of human milk fat globule (HMFG) and a hybridoma that produces 11D10. The hybridoma that produces 11D10 was selected by specific procedures. 11D10 inducts an Immunological response to HMFG in mice, rabbits, monkeys and patients with advanced HMFG-associated tumors. This invention provides compositions derived from polynucleotide sequences encoding the variable light and/or variable heavy regions of monoclonal anti-idiotype antibody 11D10, as well as polypeptides encoded thereby. The invention also provides compositions which can be used in the detection or treatment of HMFG-associated tumors.

    Abstract translation: 本发明提供了针对人乳脂肪球（HMFG）的高分子量粘蛋白和产生11D10的杂交瘤的特异性表位引起免疫应答的单克隆和独特型抗体11D10。 通过具体程序选择产生11D10的杂交瘤。 11D10在小鼠，兔，猴和晚期HMFG相关肿瘤患者中引起对HMFG的免疫应答。 本发明提供衍生自编码单克隆抗独特型抗体11D10的可变轻和/或可变重区的多核苷酸序列的组合物，以及由此编码的多肽。 本发明还提供可用于检测或治疗HMFG相关肿瘤的组合物。

    Methods for analyzing the insertion capabilities of modified group II introns
    4.
    发明授权
    Methods for analyzing the insertion capabilities of modified group II introns 有权
    分析修饰组II内含子插入能力的方法

    公开(公告)号：US07592161B2

    公开(公告)日：2009-09-22

    申请号：US10277643

    申请日：2002-10-22

    Applicant: Alan M. Lambowitz ,  Huatao Guo ,  Michael Karberg

    Inventor： Alan M. Lambowitz ,  Huatao Guo ,  Michael Karberg

    IPC: C12P19/34 ,  C12P12/06

    CPC classification number: C12N15/1058 ,  C12N9/22 ,  C12N15/102 ,  C12N15/1082 ,  C12N15/11 ,  C12N15/63 ,  C12N15/90

    Abstract: The present invention provides a system and methods for analyzing the function of nucleotide integrases and modified group II introns. The system comprises a donor plasmid comprising a wild-type or modified group II intron, a recipient plasmid comprising a DNA recognition site and a promoterless reporter gene downstream of the DNA target site, and a host cell. The method comprises the steps of transforming a host cell with the donor and recipient plasmids, assaying for expression of the reporter gene, isolating plasmid DNA from the cotransformed cells, and analyzing the plasmid DNA to confirm that the group II intron has been inserted into the target sequence. The present invention also provides a method for simultaneously analyzing the activity of two or more modified nucleotide integrases. The present invention also relates to methods of preparing a library of donor plasmids containing a plurality of diverse modified group II intron DNA sequences.

    Abstract translation: 本发明提供了用于分析核苷酸整合酶和修饰的II组内含子的功能的系统和方法。 该系统包含包含野生型或修饰的II族内含子的供体质粒，包含DNA靶位点下游的DNA识别位点和无启动子报告基因的受体质粒和宿主细胞。 该方法包括以下步骤：用供体和受体质粒转化宿主细胞，测定报道基因的表达，从共转化的细胞中分离质粒DNA，并分析质粒DNA以证实第II组内含子已插入 目标序列。 本发明还提供了一种同时分析两种或更多种修饰的核苷酸整合酶的活性的方法。 本发明还涉及制备含有多个不同修饰的II组内含子DNA序列的供体质粒文库的方法。

    Identification and cloning of a novel human gene, RET16, involved in the intracellular signaling cascade
    5.
    发明授权
    Identification and cloning of a novel human gene, RET16, involved in the intracellular signaling cascade 失效
    鉴定和克隆参与细胞内信号传导级联的新型人基因RET16

    公开(公告)号：US07198911B2

    公开(公告)日：2007-04-03

    申请号：US10077111

    申请日：2002-02-15

    Applicant: C. Gordon Todderud ,  Joshua Finger ,  Jill Rillema

    Inventor： C. Gordon Todderud ,  Joshua Finger ,  Jill Rillema

    IPC: C12P12/06 ,  C12Q1/68 ,  C12N15/63 ,  C07H21/02 ,  C07H21/04

    CPC classification number: C07K14/47

    Abstract: The present invention describes a newly discovered polynucleotide encoding a protein involved in the cell signaling cascade, called RET16, cloned, isolated and identified from TNF-alpha stimulated human microvascular endothelial cells, as well as mouse and rat RET16 orthologs thereof. Also described are the RET16 polypeptide sequence, expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies related to the polynucleotide and/or polypeptide of the present invention. Methods for screening for modulators, particularly inhibitors, of the human RET16 protein, and use of the RET16 polynucleotide and polypeptide for therapeutics and diagnostics are described.

    Abstract translation: 本发明描述了一种新发现的多核苷酸，其编码参与由TNF-α刺激的人微血管内皮细胞以及小鼠和大鼠RET16直系同源物克隆，分离和鉴定的细胞信号级联的称为RET16的蛋白质。 还描述了与本发明的多核苷酸和/或多肽相关的RET16多肽序列，表达载体，宿主细胞，激动剂，拮抗剂，反义分子和抗体。 描述了用于筛选人RET16蛋白的调节剂，特别是抑制剂的方法，以及RET16多核苷酸和多肽用于治疗和诊断的用途。

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