发明授权
- 专利标题： Bicyclic anilide spirohydantoin CGRP receptor antagonists
- 专利标题（中）： 双联苯胺西酞司酮CGRP受体拮抗剂
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申请号： US10549338申请日： 2004-03-10
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公开(公告)号： US07202251B2公开(公告)日： 2007-04-10
- 发明人: Ian M. Bell , Steven N. Gallicchio , Cory R. Theberge , Xu-Fang Zhang , Craig Stump , C. Blair Zartman
- 申请人： Ian M. Bell , Steven N. Gallicchio , Cory R. Theberge , Xu-Fang Zhang , Craig Stump , C. Blair Zartman
- 申请人地址： US NJ Rahway
- 专利权人： Merck & Co., Inc.
- 当前专利权人： Merck & Co., Inc.
- 当前专利权人地址： US NJ Rahway
- 代理商 David L. Rose; David Rubin
- 国际申请： PCT/US2004/007289 WO 20040310
- 国际公布： WO2004/082605 WO 20040930
- 主分类号： A61K31/506
- IPC分类号： A61K31/506 ; A61K31/513 ; A61K31/437 ; A61K31/438 ; A61K31/454 ; A61K31/4439 ; A61K31/427 ; A61K31/423 ; A61K31/4184 ; A61K31/4166 ; C07D239/34 ; C07D239/42 ; C07D211/98 ; C07D211/32 ; C07D277/38 ; C07D277/68 ; C07D235/26
摘要：
The present invention is directed to compounds of the formula: that are antagonists of CGRP receptors and that are useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
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