发明授权
US07202256B2 Proline CCI-779, production of and uses therefor, and two-step enzymatic synthesis of proline CCI-779 and CCI-779
失效
脯氨酸CCI-779，其生产和用途，以及脯氨酸CCI-779和CCI-779的两步酶合成
- 专利标题： Proline CCI-779, production of and uses therefor, and two-step enzymatic synthesis of proline CCI-779 and CCI-779
- 专利标题（中）： 脯氨酸CCI-779，其生产和用途，以及脯氨酸CCI-779和CCI-779的两步酶合成
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申请号： US11103779申请日： 2005-04-12
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公开(公告)号： US07202256B2公开(公告)日： 2007-04-10
- 发明人: Jianxin Gu , Mark E. Ruppen , Panolil Raveendranath , Warren Chew , Chia-Cheng Shaw
- 申请人： Jianxin Gu , Mark E. Ruppen , Panolil Raveendranath , Warren Chew , Chia-Cheng Shaw
- 申请人地址： US NJ Madison
- 专利权人： Wyeth
- 当前专利权人： Wyeth
- 当前专利权人地址： US NJ Madison
- 代理机构： Howson & Howson LLP
- 代理商 Arnold S. Milowsky
- 主分类号： C07D498/18
- IPC分类号： C07D498/18 ; C07D498/22 ; A61K31/435 ; A61K31/436
摘要：
Methods for the synthesis of CCI-779 and proline-CCI-779 are described, including a method involving lipase-catalyzed acetylation of 42-hydroxy of rapamycin with a vinyl ester of 2,2-bis(hydroxymethyl) propionic acid in an organic solvent followed by deprotection. Also provided are products containing proline-CCI-779 and uses thereof.