Invention Grant
- Patent Title: Recombinant RSV virus expression systems and vaccines
- Patent Title (中): 重组RSV病毒表达系统和疫苗
-
Application No.: US10975060Application Date: 2004-10-25
-
Publication No.: US07205013B2Publication Date: 2007-04-17
- Inventor: Hong Jin , Roderick Tang , Shengqiang Li , Martin Bryant
- Applicant: Hong Jin , Roderick Tang , Shengqiang Li , Martin Bryant
- Applicant Address: US CA Mountain View
- Assignee: MedImmune Vaccines, Inc.
- Current Assignee: MedImmune Vaccines, Inc.
- Current Assignee Address: US CA Mountain View
- Agency: MedImmune Vaccines, Inc.
- Main IPC: A01N63/00
- IPC: A01N63/00 ; A61K39/12 ; A61K39/155 ; C12N7/00 ; C12N7/02 ; C12N7/04 ; C07H21/04
Abstract:
The present invention relates to genetically engineered recombinant respiratory syncytial viruses and viral vectors which contain deletions of various viral accessory gene(s) either singly or in combination. In accordance with the present invention, the recombinant respiratory syncytial viral vectors and viruses are engineered to contain complete deletions of the M2-2, NS1, NS2, or SH viral accessory genes or various combinations thereof. In addition, the present invention relates to the attenuation of respiratory syncytial virus by mutagenisis of the M2-1 gene.
Public/Granted literature
- US20050084947A1 Recombinant RSV virus expression systems and vaccines Public/Granted day:2005-04-21
Information query
