发明授权
US07205317B2 4[piperidin-4-yliden-(3-carbamoylpheny)methyl]benzamide derivatives and their use for the treatment of pain spinal injuries or gastrointestinal disorders
失效
4 [哌啶-4-亚基 - (3-氨基甲酰基苯基)甲基]苯甲酰胺衍生物及其用于治疗疼痛脊髓损伤或胃肠道疾病
- 专利标题: 4[piperidin-4-yliden-(3-carbamoylpheny)methyl]benzamide derivatives and their use for the treatment of pain spinal injuries or gastrointestinal disorders
- 专利标题(中): 4 [哌啶-4-亚基 - (3-氨基甲酰基苯基)甲基]苯甲酰胺衍生物及其用于治疗疼痛脊髓损伤或胃肠道疾病
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申请号: US10491263申请日: 2002-10-02
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公开(公告)号: US07205317B2公开(公告)日: 2007-04-17
- 发明人: William Brown , Christopher Walpole , Zhongyong Wei
- 申请人: William Brown , Christopher Walpole , Zhongyong Wei
- 申请人地址: SE Sodertalje
- 专利权人: AstraZeneca AB
- 当前专利权人: AstraZeneca AB
- 当前专利权人地址: SE Sodertalje
- 代理商 Jianzhong Shen; Jacqueline M. Cohen
- 优先权: SE0103313 20011003
- 国际申请: PCT/SE02/01804 WO 20021002
- 国际公布: WO03/029215 WO 20030410
- 主分类号: A61K31/4528
- IPC分类号: A61K31/4528 ; A61K31/4535 ; C07D211/08
摘要:
Compounds of general formula (I) wherein R1 is selected from any one of phenyl, pyridinyl, thienyl, furanyl, imidazolyl, pyrrolyl and triazolyl; where each R1 phenyl ring and R1 heteroaromatic ring may optionally and independently be further substituted by 1, 2 or 3 substituents selected from straight and branched C1–C6 alkyl, NO2, CF3, C1–C6 alkoxy, chloro, fluoro, bromo, and iodo. The substitutions on thephenyl ring and on the heteroaromatic ring may take place in any position on said ring systems; are disclosed and claimed in the present application, as well as their pharmaceutically acceptable salts and pharmaceutical compositions comprising the novel compounds and their use in therapy, inparticular in the management of pain.
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