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25 条记录 (耗时 0.026 秒)

    4-(phenyl-piperidin-4-ylidene-methyl)-benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders
    3.
    发明授权
    4-(phenyl-piperidin-4-ylidene-methyl)-benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders 失效
    4-（苯基 - 哌啶-4-亚基 - 甲基） - 苯甲酰胺衍生物及其用于治疗疼痛，焦虑或胃肠道疾病

    公开(公告)号：US07022715B2

    公开(公告)日：2006-04-04

    申请号：US10477851

    申请日：2002-05-16

    申请人： William Brown ,  Christopher Walpole ,  Zhongyong Wei

    发明人： William Brown ,  Christopher Walpole ,  Zhongyong Wei

    IPC分类号： A61K31/445 ,  A61K31/451 ,  C07D211/08

    CPC分类号： C07D401/06 ,  C07D211/58 ,  C07D405/06 ,  C07D409/06 ,  C07D417/06

    摘要： Compounds of general formula I: R1 is selected from any one of phenyl, pyridinyl, pyrrolyl, thienyl, furanyl, imidazolyl, triazolyl, thiazolyl and pyridine N-oxide; where each R1 phenyl ring and R1 heteroaromatic ring may optionally and independently be further substituted by 1, 2 or 3 substituents selected from straight and branched C1–C?6? alkyl, NO2, CF3, C1–C6 alkoxy, chloro, fluoro, bromo, and iodo. The substitutions on the phenyl ring and on the heteroaromatic ring may take place in any position on said ring systems; are disclosed and claimed in the present application, as well as salts and pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain, anxiety and functional gastrointestinal disorders.

    摘要翻译： 通式I：R 1的化合物选自苯基，吡啶基，吡咯基，噻吩基，呋喃基，咪唑基，三唑基，噻唑基和吡啶N-氧化物中的任何一种; 其中每个R 1苯基环和R 1'杂芳环可以任选地和独立地被1,2或3个选自直链和支链C 1的取代基取代， -C≡6 烷基，NO 2，CF 3，C 1 -C 6烷氧基，氯，氟，溴，和 碘。 苯环上和杂芳环上的取代可以在所述环体系上的任何位置进行; 在本申请中公开和要求保护，以及包含新化合物的盐和药物组合物及其在治疗中的用途，特别是在治疗疼痛，焦虑和功能性胃肠道疾病中的用途。

    4[piperidin-4-yliden-(3-carbamoylpheny)methyl]benzamide derivatives and their use for the treatment of pain spinal injuries or gastrointestinal disorders
    5.
    发明授权
    4[piperidin-4-yliden-(3-carbamoylpheny)methyl]benzamide derivatives and their use for the treatment of pain spinal injuries or gastrointestinal disorders 失效
    4 [哌啶-4-亚基 - （3-氨基甲酰基苯基）甲基]苯甲酰胺衍生物及其用于治疗疼痛脊髓损伤或胃肠道疾病

    公开(公告)号：US07205317B2

    公开(公告)日：2007-04-17

    申请号：US10491263

    申请日：2002-10-02

    申请人： William Brown ,  Christopher Walpole ,  Zhongyong Wei

    发明人： William Brown ,  Christopher Walpole ,  Zhongyong Wei

    IPC分类号： A61K31/4528 ,  A61K31/4535 ,  C07D211/08

    CPC分类号： C07D401/06 ,  C07D211/70 ,  C07D405/06 ,  C07D409/06 ,  C07D417/06

    摘要： Compounds of general formula (I) wherein R1 is selected from any one of phenyl, pyridinyl, thienyl, furanyl, imidazolyl, pyrrolyl and triazolyl; where each R1 phenyl ring and R1 heteroaromatic ring may optionally and independently be further substituted by 1, 2 or 3 substituents selected from straight and branched C1–C6 alkyl, NO2, CF3, C1–C6 alkoxy, chloro, fluoro, bromo, and iodo. The substitutions on thephenyl ring and on the heteroaromatic ring may take place in any position on said ring systems; are disclosed and claimed in the present application, as well as their pharmaceutically acceptable salts and pharmaceutical compositions comprising the novel compounds and their use in therapy, inparticular in the management of pain.

    摘要翻译： 通式（I）的化合物，其中R 1选自苯基，吡啶基，噻吩基，呋喃基，咪唑基，吡咯基和三唑基中的任一个; 其中每个R 1苯基环和R 1'杂芳环可以任选地和独立地被1,2或3个选自直链和支链C 1的取代基取代， C 1 -C 6烷基，NO 2，CF 3，C 1 -C 6烷基，C 1 -C 6烷基， 烷氧基，氯，氟，溴和碘。 苯环上和杂芳环上的取代可以在所述环体系上的任何位置进行; 在本申请中公开和要求保护，以及它们的药学上可接受的盐和药物组合物，其包含新化合物及其在治疗中的用途，特别是在疼痛的管理中。

    Compounds with analgesic effect
    10.
    发明授权
    Compounds with analgesic effect 失效
    化合物具有镇痛作用

    公开(公告)号：US06187792B1

    公开(公告)日：2001-02-13

    申请号：US09029633

    申请日：1998-03-05

    申请人： Daniel Delorme ,  Edward Roberts ,  Zhongyong Wei

    发明人： Daniel Delorme ,  Edward Roberts ,  Zhongyong Wei

    IPC分类号： A61K31445

    CPC分类号： C07D401/06 ,  C07D211/46 ,  C07D211/70 ,  C07D405/06

    摘要： Compounds of general formula (I) are disclosed and claimed in the present application, as well as their pharmaceutically acceptable salts, pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain.

    摘要翻译： 通式（I）的化合物在本申请中公开和要求保护，以及它们的药学上可接受的盐，包含新化合物的药物组合物及其在治疗中的用途，特别是用于治疗疼痛。