发明授权
- 专利标题： Process for preparing peptidyl heterocyclic ketone derivatives
- 专利标题（中）： 肽基杂环酮衍生物的制备方法
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申请号： US10902755申请日： 2004-07-29
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公开(公告)号： US07205384B2公开(公告)日： 2007-04-17
- 发明人: Michael Breslav , Bruce Harris , Birdella Kenney , Thomas Maier , Armin Roessler , Frank Villani , Ulrich Weigl , Fan Zhang-Plasket , Hua Zhong
- 申请人： Michael Breslav , Bruce Harris , Birdella Kenney , Thomas Maier , Armin Roessler , Frank Villani , Ulrich Weigl , Fan Zhang-Plasket , Hua Zhong
- 申请人地址： US NJ Raritan
- 专利权人： Ortho-McNeil Pharmaceutical Inc.
- 当前专利权人： Ortho-McNeil Pharmaceutical Inc.
- 当前专利权人地址： US NJ Raritan
- 主分类号： A61K38/00
- IPC分类号： A61K38/00
摘要：
The present invention relates to novel processes for the preparation of peptidyl heterocyclic ketones of the general formula (I) wherein all variables are as herein defined. The present invention further relates to novel pharmaceutical salts and processes for their preparation. The peptidyl heterocyclic ketones of formula (I) are potent and selective inhibitors of tryptase, useful for the treatment and prevention of inflammatory diseases associated with the respiratory tract, such as asthma and allergic rhinitis.