A decision sequence generating method and an associated receiver with a decision feedback equalizer (DFE) are provided. The receiver can mitigate multi-path distortion generated when data is transmitted through a multi-path channel, wherein the data is encoded into codewords, each of which comprises N chips. The receiver comprises a decision generator for generating N−1 chip decisions corresponding to first N−1 chips of a received codeword and for producing a codeword decision corresponding to the whole received codeword; and a feedback filter for reconstructing post-cursor section of the multi-path channel impulse response. The decision sequence generating method comprises sending the N−1 chip decisions into the feedback filter in order, producing the codeword decision after collecting all N chips of the received codeword, and then providing the codeword decision to the feedback filter to replace the N−1 chip decisions sent previously, thereby reconstructing the post-cursor section of the channel impulse response with more confidence.