发明授权
US07211666B2 Methods for the preparation of pyrrolotriazine compounds useful as kinase inhibitors
有权
制备用作激酶抑制剂的吡咯并三嗪化合物的方法
- 专利标题： Methods for the preparation of pyrrolotriazine compounds useful as kinase inhibitors
- 专利标题（中）： 制备用作激酶抑制剂的吡咯并三嗪化合物的方法
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申请号： US11019788申请日： 2004-12-22
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公开(公告)号： US07211666B2公开(公告)日： 2007-05-01
- 发明人: Jollie Duaine Godfrey, Jr. , John Hynes, Jr. , Alaric J. Dyckman , Katerina Leftheris , Zhongping Shi , Stephen T. Wrobleski , Wendel William Doubleday , John A. Grosso
- 申请人： Jollie Duaine Godfrey, Jr. , John Hynes, Jr. , Alaric J. Dyckman , Katerina Leftheris , Zhongping Shi , Stephen T. Wrobleski , Wendel William Doubleday , John A. Grosso
- 申请人地址： US NJ Princeton
- 专利权人： Bristol-Myers Squibb Company
- 当前专利权人： Bristol-Myers Squibb Company
- 当前专利权人地址： US NJ Princeton
- 代理商 Joseph C. Wang
- 主分类号： C07D487/04
- IPC分类号： C07D487/04 ; C07D207/36
摘要：
Methods of preparing kinase inhibiting pharmaceutical compounds having the formula (I): or a pharmaceutically acceptable salt or solvate thereof, wherein R1 through R6 and Z are as described in the specification. The methods according to the invention utilize an amination process, in which a pyrrole is reacted with a haloamine, preferably chloramine. This step is followed by cyclization to form the pyrrolotriazine core.
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