发明授权
- 专利标题： Methods of inhibiting TNFα in patients with neoplastic disease
- 专利标题（中）： 抑制肿瘤性疾病患者TNFalpha的方法
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申请号： US10010229申请日： 2001-12-07
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公开(公告)号： US07214376B2公开(公告)日： 2007-05-08
- 发明人: Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel
- 申请人： Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel
- 申请人地址： US NY New York US PA Malvern
- 专利权人： New York University,Centocor, Inc.
- 当前专利权人： New York University,Centocor, Inc.
- 当前专利权人地址： US NY New York US PA Malvern
- 代理机构： Hamilton, Brook, Smith & Reynolds, P.C.
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; C07K16/28
摘要：
Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.
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